Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits

Gratuze Maud; Holtzman David M.

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Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits

机译：针对突触前的Tau积累：抵消TAU介导的突触损失和记忆赤字的新策略

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Synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in Alzheimer's disease and tauopathies. In this issue of Neuron, Largo-Barrientos et al. report that synaptic loss can be mitigated by lowering Synaptogyrin-3, a known mediator of tau binding to synaptic vesicles.

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《Neuron》 |2021年第5期|共3页
作者
Gratuze Maud; Holtzman David M.;
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Washington Univ Sch Med Knight Alzheimers Dis Res Ctr Hope Ctr Neurol Disorders Dept Neurol St;

Washington Univ Sch Med Knight Alzheimers Dis Res Ctr Hope Ctr Neurol Disorders Dept Neurol St;

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正文语种 eng
中图分类神经病学;
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2. The local mammalian target of rapamycin (mTOR) modulation:a promising strategy to counteract neurodegeneration [J] . Diego Dolcetta, Roberto Dominici 中国神经再生研究（英文版） . 2019,第010期
3. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38 gamma [J] . Ittner Arne, Asih Prita Riana, Tan Amanda R. P., Acta Neuropathologica . 2020,第3期

机译：通过地图激酶P38伽玛减少先进的TAU介导的记忆缺陷
4. Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A(2A) receptor [J] . Carvalho Kevin, Faivre Emilie, Pietrowski Marie J., Brain: A journal of neurology . 2019,第Pta11期

机译：与神经元腺苷A（2A）受体相关的TAU病理学中C1Q失效，突触丢失和记忆缺陷
5. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. [J] . Schindowski K, Bretteville A, Leroy K, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2006,第2期

机译：阿尔茨海默氏病样tau神经病理学导致记忆缺陷和新型突变tau转基因小鼠的功能性突触丧失，而没有任何运动缺陷。
6. NEW TRAINING AND DIAGNOSTIC STRATEGIES TO COUNTERACT MUSCLE AND BONE LOSS IN MICROGRAVITY [C] . Talla R., Adamcik G., Barta N., Life in space for life on earth conference . 2013

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7. Testing the view that the semantic memory deficit in Alzheimer's disease reflects a loss of semantic knowledge. [D] . Alathari, Lina. 2002

机译：测试关于阿尔茨海默氏病的语义记忆缺陷反映了语义知识损失的观点。
8. PNAS Plus: Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling [O] . Yaling Yin, Di Gao, Yali Wang, 2016

机译：PNAS Plus：Tau积累通过钙调神经磷酸酶介导的CaMKIV / CREB核信号的失活诱导突触损伤和记忆障碍
9. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. [O] . Hongjun Fu, S Abid Hussaini, Susanne Wegmann, 2016

机译：Tau病理学的时空传播的三维可视化揭示了老年Tau转基因小鼠中与神经元丢失和识别记忆缺陷相关的Tau积累的广泛位点。

Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits

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