A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment

Huang Xiaodan; Huang Pengcheng; Huang Lu; Hu Zhengfang; Liu Xianwei; Shen Jiawei; Xi Yue; Yang Yan; Fu Yunwei; Tao Qian; Lin Song; Xu Anding; Xu Fuqiang; Xue Tian; So Kwok-Fai; Li Haohong; Ren Chaoran

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A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment

机译：与核心促进光处理的空间记忆促进效果有关的视觉电路

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摘要

Light exerts profound effects on cognitive functions across species, including humans. However, the neuronal mechanisms underlying the effects of light on cognitive functions are poorly understood. In this study, we show that long-term exposure to bright-light treatment promotes spatial memory through a di-synaptic visual circuit related to the nucleus reuniens (Re). Specifically, a subset of SMI-32-expressing ON-type retinal ganglion cells (RGCs) innervate CaMKII alpha neurons in the thalamic ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL), which in turn activate CaMKII alpha neurons in the Re. Specific activation of vLGN/IGL-projecting RGCs, activation of Re-projecting vLGN/IGL neurons, or activation of postsynaptic Re neurons is sufficient to promote spatial memory. Furthermore, we demonstrate that the spatial-memory-promoting effects of light treatment are dependent on the activation of vLGN/IGL-projecting RGCs, Re-projecting vLGN/IGL neurons, and Re neurons. Our results reveal a dedicated subcortical visual circuit that mediates the spatial-memory-promoting effects of light treatment.

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《Neuron》 |2021年第2期|共23页
作者
Huang Xiaodan; Huang Pengcheng; Huang Lu; Hu Zhengfang; Liu Xianwei; Shen Jiawei; Xi Yue; Yang Yan; Fu Yunwei; Tao Qian; Lin Song; Xu Anding; Xu Fuqiang; Xue Tian; So Kwok-Fai; Li Haohong; Ren Chaoran;
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作者单位

Jinan Univ Guangdong Hongkong Macau Inst CNS Regenerat Minist Educ CNS Regenerat Collaborat;

Huazhong Univ Sci &

Technol Wuhan Natl Lab Optoelect Collaborat Innovat Ctr Biomed Engn Sch Engn;

Jinan Univ Guangdong Hongkong Macau Inst CNS Regenerat Minist Educ CNS Regenerat Collaborat;

Jinan Univ Guangdong Hongkong Macau Inst CNS Regenerat Minist Educ CNS Regenerat Collaborat;

Jinan Univ Guangdong Hongkong Macau Inst CNS Regenerat Minist Educ CNS Regenerat Collaborat;

Chinese Acad Sci Hefei Natl Lab Phys Sci Microscale Neurodegenerat Disorder Res Ctr Univ Sci &

Jinan Univ Guangdong Hongkong Macau Inst CNS Regenerat Minist Educ CNS Regenerat Collaborat;

Jinan Univ Guangdong Hongkong Macau Inst CNS Regenerat Minist Educ CNS Regenerat Collaborat;

Jinan Univ Guangdong Hongkong Macau Inst CNS Regenerat Minist Educ CNS Regenerat Collaborat;

Jinan Univ Sch Med Psychol Dept Guangzhou 510632 Peoples R China;

Jinan Univ Sch Med Physiol Dept Guangzhou 510632 Peoples R China;

Jinan Univ Dept Neurol Affiliated Hosp 1 Guangzhou 510632 Peoples R China;

Chinese Acad Sci Brain Cognit &

Brain Dis Inst BCBDI Shenzhen Inst Adv Technol CAS Key Lab Brain;

Chinese Acad Sci Hefei Natl Lab Phys Sci Microscale Neurodegenerat Disorder Res Ctr Univ Sci &

Jinan Univ Guangdong Hongkong Macau Inst CNS Regenerat Minist Educ CNS Regenerat Collaborat;

Huazhong Univ Sci &

Technol Wuhan Natl Lab Optoelect Collaborat Innovat Ctr Biomed Engn Sch Engn;

Jinan Univ Guangdong Hongkong Macau Inst CNS Regenerat Minist Educ CNS Regenerat Collaborat;

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正文语种 eng
中图分类神经病学;
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A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment

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