A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing

Seo Dong-oh; Zhang Eric T.; Piantadosi Sean C.; Marcus David J.; Motard Laura E.; Kan Bryce K.; Gomez Adrian M.; Nguyen Tammy K.; Xia Li; Bruchas Michael R.

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A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing

机译：牙科队的诊断与齿状齿轮Gyrus Oreadrenergic电路调制厌恶上下文处理

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Dysregulation in contextual processing is believed to affect several forms of psychopathology, such as post traumatic stress disorder (PTSD). The dentate gyrus (DG), a subregion of the hippocampus, is thought to be an important brain region for disambiguating new experiences from prior experiences. Noradrenergic (NE) neurons in the locus coeruleus (LC) are more tonically active during stressful events and send dense projections to the DG, yet an understanding of their function in DG-dependent contextual discrimination has not been established. Here, we isolate a key function of the LC-NE-DG circuit in contextual aversive generalization using selective manipulations and in vivo single-cell calcium imaging. We report that activation of LC-NE neurons and terminal activity results in contextual generalization. We found that these effects required b-adrenergic-medi-ated modulation of hilar interneurons to ultimately promote aversive generalization, suggesting that disruption of noradrenergic tone may serve as an important avenue for treating stress-induced disorders.

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《Neuron》 |2021年第13期|共22页
作者
Seo Dong-oh; Zhang Eric T.; Piantadosi Sean C.; Marcus David J.; Motard Laura E.; Kan Bryce K.; Gomez Adrian M.; Nguyen Tammy K.; Xia Li; Bruchas Michael R.;
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Washington Univ Dept Anesthesiol Div Basic Res Sch Med St Louis MO 63110 USA;

Univ Washington Dept Bioengn Seattle WA 98105 USA;

Univ Washington Dept Anesthesiol &

Pain Med Seattle WA 98195 USA;

Univ Washington Dept Anesthesiol &

Pain Med Seattle WA 98195 USA;

Washington Univ Dept Anesthesiol Div Basic Res Sch Med St Louis MO 63110 USA;

Univ Washington Dept Anesthesiol &

Pain Med Seattle WA 98195 USA;

Washington Univ Dept Anesthesiol Div Basic Res Sch Med St Louis MO 63110 USA;

Univ Washington Dept Anesthesiol &

Pain Med Seattle WA 98195 USA;

Washington Univ Div Biol &

Biomed Sci Sch Med St Louis MO 63110 USA;

Washington Univ Dept Anesthesiol Div Basic Res Sch Med St Louis MO 63110 USA;

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正文语种 eng
中图分类神经病学;
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1. Degenerative alterations in noradrenergic neurons of the locus coeruleus in Alzheimer’s disease**** [J] . Lihua Liu, Saiping Luo, Leping Zeng, 中国神经再生研究（英文版） . 2013,第024期
2. Melatonin modifies SOX2+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation [J] . Alan Hinojosa-Godínez, Luis F. Jave-Suarez, Mario Flores-Soto, 中国神经再生研究（英文版） . 2019,第010期
3. Priming locus coeruleus noradrenergic modulation of medial perforant path-dentate gyrus synaptic plasticity [J] . Rajkumar Ramamoorthy, Kumar Jigna Rajesh, Dawe Gavin S. Neurobiology of learning and memory . 2017,第期

机译：喷灌基因座Coeruleus Noadynergic调制内侧穿孔路径齿状转酸突触塑性
4. Medial and lateral perforant path evoked potentials are selectively modulated by pairing with glutamatergic activation of locus coeruleus in the dentate gyrus of the anesthetized rat [J] . EdisonH.T., HarleyC.W. Hippocampus . 2012,第3期

机译：通过与麻醉大鼠齿状回中的蓝斑轨迹的谷氨酸能激活配对来选择性调节内侧和外侧穿孔路径诱发电位
5. Effects of lesioning noradrenergic neurones in the locus coeruleus on conditioned and unconditioned aversive behaviour in the rat. [J] . Neophytou SI, Aspley S, Butler S, Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal . 2001,第6期

机译：蓝斑中受损的去甲肾上腺素能神经元对大鼠条件性和非条件性厌恶行为的影响。
6. Circuit modeling for super-high speed processing spatially modulated field signals [C] . Kouzaev, G.A., Tcherkasov, . 1998

机译：用于超高速处理空间调制场信号的电路建模
7. Glutamatergic activation of locus coeruleus induces selective noradrenergic modulation of medial and lateral perforant path evoked potentials in the dentate gyrus of the anaesthetized rat. [D] . Edison, Hilary T. 2010

机译：谷氨酸的谷氨酸能激活在麻醉的大鼠的齿状回中诱导选择性的去甲肾上腺素能调节内侧和外侧穿孔路径诱发的电位。
8. Locus Coeruleus Optogenetic Light Activation Induces Long-Term Potentiation of Perforant Path Population Spike Amplitude in Rat Dentate Gyrus [O] . Meghan A. L. Quinlan, Vanessa M. Strong, Darlene M. Skinner, 2018

机译：蓝斑基因光遗传光激活诱导大鼠齿状回的穿孔路径种群峰值幅度的长期增强。
9. Priming locus coeruleus noradrenergic modulation of medial perforant path-dentate gyrus synaptic plasticity [O] . Rajkumar Ramamoorthy, Kumar Jigna Rajesh, Dawe Gavin S. 2016

机译：初发轨迹蓝藻去甲肾上腺素能调节内侧穿孔-齿状回突触可塑性

A locus coeruleus to dentate gyrus noradrenergic circuit modulates aversive contextual processing

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