Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Cserep Csaba; Posfai Balazs; Denes Adam

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Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

机译：塑造神经元命运：直接微胶鸡 - 神经元相互作用的功能异质性

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The functional contribution of microglia to normal brain development, healthy brain function, and neurological disorders is increasingly recognized. However, until recently, the nature of intercellular interactions mediating these effects remained largely unclear. Recent findings show microglia establishing direct contact with different compartments of neurons. Although communication between microglia and neurons involves intermediate cells and soluble factors, direct membrane contacts enable a more precisely regulated, dynamic, and highly effective form of interaction for fine-tuning neuronal responses and fate. Here, we summarize the known ultrastructural, molecular, and functional features of direct microglia-neuron interactions and their roles in brain disease.

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《Neuron》 |2021年第2期|共19页
作者
Cserep Csaba; Posfai Balazs; Denes Adam;
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作者单位

Inst Expt Med Momentum Lab Neuroimmunol Szigony U 43 H-1083 Budapest Hungary;

Inst Expt Med Momentum Lab Neuroimmunol Szigony U 43 H-1083 Budapest Hungary;

Inst Expt Med Momentum Lab Neuroimmunol Szigony U 43 H-1083 Budapest Hungary;

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正文语种 eng
中图分类神经病学;
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Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

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