Machine Perfusions in Liver Transplantation: The Evidence-Based Position Paper of the Italian Society of Organ and Tissue Transplantation

Ghinolfi Davide; Lai Quirino; Dondossola Daniele; De Carlis Riccardo; Zanierato Marinella; Patrono Damiano; Baroni Stefano; Bassi Domenico; Ferla Fabio; Lauterio Andrea; Lazzeri Chiara; Magistri Paolo; Melandro Fabio; Pagano Duilio; Pezzati Daniele; Ravaioli Matteo; Rreka Erion; Toti Luca; Zanella Alberto; Burra Patrizia; Petta Salvatore; Rossi Massimo; Dutkowski Philippe; Jassem Wayel; Muiesan Paolo; Quintini Cristiano; Selzner Markus; Cillo Umberto

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Machine Perfusions in Liver Transplantation: The Evidence-Based Position Paper of the Italian Society of Organ and Tissue Transplantation

机译：肝移植机灌注：意大利器官和组织移植学会的基于证据的位置纸

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The use of machine perfusion (MP) in liver transplantation (LT) is spreading worldwide. However, its efficacy has not been demonstrated, and its proper clinical use has far to go to be widely implemented. The Societa Italiana Trapianti d'Organo (SITO) promoted the development of an evidence-based position paper. A 3-step approach has been adopted to develop this position paper. First, SITO appointed a chair and a cochair who then assembled a working group with specific experience of MP in LT. The Guideline Development Group framed the clinical questions into a patient, intervention, control, and outcome (PICO) format, extracted and analyzed the available literature, ranked the quality of the evidence, and prepared and graded the recommendations. Recommendations were then discussed by all the members of the SITO and were voted on via the Delphi method by an institutional review board. Finally, they were evaluated and scored by a panel of external reviewers. All available literature was analyzed, and its quality was ranked. A total of 18 recommendations regarding the use and the efficacy of ex situ hypothermic and normothermic machine perfusion and sequential normothermic regional perfusion and ex situ MP were prepared and graded according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. A critical and scientific approach is required for the safe implementation of this new technology.

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来源
《Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society》 |2020年第10期|共18页
作者
Ghinolfi Davide; Lai Quirino; Dondossola Daniele; De Carlis Riccardo; Zanierato Marinella; Patrono Damiano; Baroni Stefano; Bassi Domenico; Ferla Fabio; Lauterio Andrea; Lazzeri Chiara; Magistri Paolo; Melandro Fabio; Pagano Duilio; Pezzati Daniele; Ravaioli Matteo; Rreka Erion; Toti Luca; Zanella Alberto; Burra Patrizia; Petta Salvatore; Rossi Massimo; Dutkowski Philippe; Jassem Wayel; Muiesan Paolo; Quintini Cristiano; Selzner Markus; Cillo Umberto;
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作者单位

Univ Pisa Med Sch Hosp Div Hepat Surg &

Liver Transplantat Via Paradisa 2 I-56124 Pisa Italy;

Sapienza Univ Rome Hepatobiliary &

Organ Transplantat Unit Rome Italy;

Univ Milan Med Sch Hosp Fdn IRCCS Ca Granda Gen &

Liver Transplantat Unit Milan Italy;

Osped Niguarda Ca Granda Dept Gen Surg &

Abdominal Transplantat Milan Italy;

Univ Turin Med Sch Hosp Gen Surg &

Liver Transplantat Turin Italy;

Univ Turin Med Sch Hosp Dept Anesthesiol Turin Italy;

Univ Modena Med Sch Hosp Dept Anesthesiol Modena Italy;

Univ Padua Med Sch Hosp Hepatobiliary Surg &

Liver Transplantat Unit Padua Italy;

Osped Niguarda Ca Granda Dept Gen Surg &

Abdominal Transplantat Milan Italy;

Osped Niguarda Ca Granda Dept Gen Surg &

Abdominal Transplantat Milan Italy;

Univ Florence Med Sch Hosp Intens Care Unit Florence Italy;

Univ Modena Med Sch Hosp Transplantat Unit Hepatopancreatobiliary Surg &

Liver Modena Italy;

Univ Pisa Med Sch Hosp Div Hepat Surg &

Liver Transplantat Via Paradisa 2 I-56124 Pisa Italy;

Ist Mediterraneo Trapianti &

Terapie Alta Special Dept Treatment &

Study Abdominal Dis &

Abdominal Palermo Italy;

Univ Pisa Med Sch Hosp Div Hepat Surg &

Liver Transplantat Via Paradisa 2 I-56124 Pisa Italy;

Univ Bologna Med Sch Hosp Dept Organ Insufficiency &

Transplantat Gen Surg &

Transplantat Bologna Italy;

Univ Pisa Med Sch Hosp Div Hepat Surg &

Liver Transplantat Via Paradisa 2 I-56124 Pisa Italy;

Univ Tor Vergata Dept Surg HPB &

Transplant Unit Rome Italy;

Univ Milan Med Sch Hosp Fdn IRCCS Ca Granda Dept Anesthesia &

Crit Care Milan Italy;

Univ Padua Med Sch Hosp Dept Surg Oncol &

Gastroenterol Padua Italy;

Univ Palermo Med Sch Hosp Div Gastroenterol &

Hepatol Palermo Italy;

Sapienza Univ Rome Hepatobiliary &

Organ Transplantat Unit Rome Italy;

Univ Hosp Zurich Dept Surg &

Transplantat Zurich Switzerland;

Kings Coll Hosp London Inst Liver Studies London England;

Univ Hosp Birmingham NHS Fdn Trust Queen Elizabeth Hosp Liver Unit Birmingham W Midlands England;

Cleveland Clin Transplant Ctr Cleveland OH 44106 USA;

Toronto Gen Hosp Dept Surg Multiorgan Transplant Program Toronto ON Canada;

Univ Padua Med Sch Hosp Hepatobiliary Surg &

Liver Transplantat Unit Padua Italy;

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正文语种 eng
中图分类肝及肝管;腹部外科学;
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1. Liver transplantation using organs from deceased organ donors：a single organ transplant center experience [J] . Ming Han, Lin-Wei Wu, An-Bin Hu, 国际肝胆胰疾病杂志（英文版） . 2014,第004期
2. Management of metabolic alterations in adult kidney transplant recipients: A joint position statement of the Italian Society of Nephrology (SIN), the Italian Society for Organ Transplantation (SITO) and the Italian Diabetes Society (SID) [J] . Conte Caterina, Maggiore Umberto, Cappelli Gianni, Nutrition, metabolism, and cardiovascular diseases: NMCD . 2020,第9期

机译：成人肾移植受者的代谢改变管理：意大利肾脏学会（SIN），意大利器官移植学会（SITO）和意大利糖尿病学会（SID）的联合立场声明
3. Implementing an innovated preservation technology: The American Society of Transplant Surgeons’ ( ASTS ASTS ) Standards Committee White Paper on Ex Situ Liver Machine Perfusion [J] . Quintini Cristiano, Martins Paulo N., Shah Shimul, American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons . 2018,第8期

机译：实施创新的保存技术：美国移植外科医生的美国学会（ASTS ASTS）标准委员会白皮书在原地肝脏机械灌注
4. Implementing an innovated preservation technology: The American Society of Transplant Surgeons' (ASTS) Standards Committee White Paper on Ex Situ Liver Machine Perfusion [J] . Quintini Cristiano, Martins Paulo N., Shah Shimul, Nature reviews Cancer . 2018,第8期

机译：实施创新的保存技术：美国移植外科医生（ASTS）标准委员会白皮书灌注
5. Development of a Multispectral Tissue Characterization System for Optimization of an Implantable Perfusion Status Monitor for Transplanted Liver [C] . J. S. Baba, B. S. Letzen, M. N. Ericson, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2009

机译：用于优化移植肝脏植入灌注状态监测系统的多光谱组织特征系统的研制
6. Thermal method for measuring perfusion in transplanted organs. [D] . Brown, Fredericka Delores. 2003

机译：测量移植器官灌注的热方法。
7. Key concepts and critical issues on epoetin and filgrastim biosimilars. A position paper from the Italian Society of Hematology Italian Society of Experimental Hematology and Italian Group for Bone Marrow Transplantation [O] . Giovanni Barosi, Alberto Bosi, Maria P. Abbracchio, 2011

机译：依泊汀和非格司亭生物仿制药的关键概念和关键问题。意大利血液学会意大利实验血液学会和意大利骨髓移植小组的立场文件
8. Supporting physicians in the management of metabolic alterations in adult kidney transplant recipients: a comment on the joint position statement of the Italian Society of Nephrology (SIN), the Italian Society for Organ Transplantation (SITO) and the Italian Diabetes Society (SID) [O] . Caterina Conte, Umberto Maggiore, Gianni Cappelli, 2020

机译：支持医生在成人肾移植受者的代谢改建管理中：关于意大利肾脏学会的联合立场声明（SIN），意大利器官移植协会（SITO）和意大利糖尿病学会（SID）的评论
9. Department of Health and Human Services, Health Care Financing Administration:Medicare and Medicaid Programs; Hospital Conditions of Participation; Identification of Potential Organ, Tissue, and Eye Donors and Transplant Hospitals' Provision of Transplant [R] . 1998

机译：卫生与公共服务部，医疗保健融资管理局：医疗保险和医疗补助计划;医院参与条件;鉴定潜在器官，组织和眼科捐赠者和移植医院提供移植

Machine Perfusions in Liver Transplantation: The Evidence-Based Position Paper of the Italian Society of Organ and Tissue Transplantation

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