Chapter 15 Macrophages and RhoA Pathway in Transplanted Organs

Yianzhu Liu; Jacek Z. Kubiak; Xian C. Li; Rafik M. Ghobrial; Malgorzata Kloc

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Chapter 15 Macrophages and RhoA Pathway in Transplanted Organs

机译：移植器官中第15章巨噬细胞和rhOA途径

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RhoA is a small GTPase that, via its downstream effectors, regulates a variety of cell functions such as cytokinesis, cell migration, vesicular trafficking, and phagocytosis. As such the RhoA pathway is also pivotal for proper functioning of immune cells including macrophages. By controlling actin cytoskeleton organization, RhoA pathway modulates macrophage's polarity and basic functions: phagocytosis, migration, and extracellular matrix degradation. Numerous studies indicate that macrophages are very important effectors contributing to acute and chronic rejection of transplanted organs. In this review we discuss the role of RhoA pathway in governance of macrophage's functions in terms of transplanted organs.

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《Results and problems in cell differentiation》 |2017年第2017期|共12页
作者
Yianzhu Liu; Jacek Z. Kubiak; Xian C. Li; Rafik M. Ghobrial; Malgorzata Kloc;
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The Houston Methodist Research Institute Houston TX USA;

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正文语种 eng
中图分类细胞生物学;
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Chapter 15 Macrophages and RhoA Pathway in Transplanted Organs

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