Histone deacetylases in virus-associated cancers

Habibollah Mirzaei; Saeed Ghorbani; Sayyad Khanizadeh; Haideh Namdari; Ebrahim Faghihloo; Abolfazl Akbari

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Histone deacetylases in virus-associated cancers

机译：病毒相关癌症中的组蛋白脱乙酰酶

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Summary Oncogenic viruses are one of the most important causes of cancer worldwide. The pathogens contribute to the establishment of human malignancies by affecting various cellular events. Epigenetic mechanisms, such as histone modification met-hylation/demethylation, are one of the most critical events manipulated by oncogenic viruses to drive tumorigenesis. Histone modifications are mediated by histone acetylation and deacetylation, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. Dysregulation of HDACs activity affects viral tumorigenesis in several ways, such as manipulating tumor suppressor and viral gene expression. The present review aims to describe the vital interactions between both cancer-caused/associated viruses and the HDAC machinery, particularly by focusing on those viruses involved in gastrointestinal tumors, as some of the most common viral-mediated cancers.

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来源
《Reviews in medical virology》 |2020年第1期|共1页
作者
Habibollah Mirzaei; Saeed Ghorbani; Sayyad Khanizadeh; Haideh Namdari; Ebrahim Faghihloo; Abolfazl Akbari;
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作者单位

Hepatitis Research Center Lorestan University of Medical Sciences Khorramabad Iran;

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原文格式 PDF
正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;
关键词
cancer; HDAC; oncogenic viruses;

机译：癌症;HDAC;致癌病毒;

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2. Class Ⅰ histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells [J] . Baoyuan Zhang, Junfang Lyu, Eun Ju Yang, 药学学报：英文版 . 2020,第004期
3. Exploratory clinical study of chidamide, an oral subtype-selective histone deacetylase inhibitor, in combination with exemestane in hormone receptor-positive advanced breast cancer [J] . Qingyuan Zhang, Tao Wang, Cuizhi Geng, 中国癌症研究（英文版） . 2018,第006期
4. P21-Driven Multifusion Gene System for Evaluating the Efficacy of Histone Deacetylase Inhibitors by In Vivo Molecular Imaging and for Transcription Targeting Therapy of Cancer Mediated by Histone Deacetylase Inhibitor [J] . Ya-Ju Hsieh, Luen Hwu, Yi-Chieh Chen, The Journal of Nuclear Medicine . 2014,第4期

机译：P21驱动的多重融合基因系统，用于通过体内分子成像评估组蛋白去乙酰化酶抑制剂的功效以及组蛋白去乙酰化酶抑制剂介导的癌症的转录靶向治疗
5. P21-driven multifusion gene system for evaluating the efficacy of histone deacetylase inhibitors by in vivo molecular imaging and for transcription targeting therapy of cancer mediated by histone deacetylase inhibitor. [J] . Ya-Ju Hsieh, Luen Hwu, Yi-Chieh Chen, The Journal of Nuclear Medicine . 2014,第4期

机译：P21驱动的多融合基因系统，用于通过体内分子成像评估组蛋白脱乙酰基酶抑制剂的功效，以及通过组蛋白脱乙酰基酶抑制剂介导的癌症的转录靶向治疗。
6. P21-driven multifusion gene system for evaluating the efficacy of histone deacetylase inhibitors by in vivo molecular imaging and for transcription targeting therapy of cancer mediated by histone deacetylase inhibitor. [J] . Ya-Ju Hsieh, Luen Hwu, Yi-Chieh Chen, The Journal of Nuclear Medicine . 2014,第4期

机译：P21驱动的多化基因系统，用于评估组蛋白脱乙酰酶抑制剂的体内分子成像和组蛋白脱乙酰酶抑制剂介导的癌症的转录靶向治疗的疗效。
7. Conjugate of Pt (Ⅳ)-Histone Deacetylase Inhibitor as Prodrug for Cancer Chemotherapy [C] . Jun Yang, Weiwei Mao, Xuanrong Sun, World biomaterials congress . 2012

机译：Pt（Ⅳ）-组蛋白脱乙酰基酶抑制剂作为癌症化学疗法的前药。
8. Application of Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-induced Cachexia [D] . Tseng, Yu-Chou. 2017

机译：组蛋白脱乙酰基酶抑制剂AR-42在癌症引起的恶病质中的应用
9. Histone Deacetylase Expressions in Hepatocellular Carcinoma and Functional Effects of Histone Deacetylase Inhibitors on Liver Cancer Cells In Vitro [O] . Kim Freese, Tatjana Seitz, Peter Dietrich, 2019

机译：组蛋白脱乙酰酶在肝细胞癌中的表达及组蛋白脱乙酰酶抑制剂对肝癌细胞的体外作用
10. Synergy between histone deacetylase inhibitors and DNA-damaging agents is mediated by histone deacetylase 2 in colorectal cancer [O] . Alzoubi S, Brody L, Rahman S, 2016

机译：组蛋白去乙酰化酶抑制剂和DNa损伤剂之间的协同作用是由结肠直肠癌中的组蛋白去乙酰化酶2介导的
11. Targeting MTA1/HIF-1alpha Signaling by Pterostilbene in Combination with Histone Deacetylase Inhibitor Attenuates Prostate Cancer Progression (Open Access). [R] . Butt, N. A., Kumar, A., Dhar, S., 2017

机译：通过紫檀芪与组蛋白去乙酰化酶抑制剂组合靶向mTa1 / HIF-1α信号减弱前列腺癌进展（开放存取）。

Histone deacetylases in virus-associated cancers

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