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首页> 外文期刊>Occupational and environmental medicine >Occupational use of high-level disinfectants and asthma incidence in early- to mid-career female nurses: a prospective cohort study
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Occupational use of high-level disinfectants and asthma incidence in early- to mid-career female nurses: a prospective cohort study

机译：职业使用高水平消毒剂和哮喘发病率早期至中等职业女性护士：一项潜在的队列研究

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Occupational use of disinfectants among healthcare workers has been associated with asthma. However, most studies are cross-sectional, and longitudinal studies are not entirely consistent. To limit the healthy worker effect, it is important to conduct studies among early- to mid-career workers. We investigated the prospective association between use of disinfectants and asthma incidence in a large cohort of early- to mid-career female nurses.The Nurses’ Health Study 3 is an ongoing, prospective, internet-based cohort of female nurses in the USA and Canada (2010–present). Analyses included 17?280 participants without a history of asthma at study entry (mean age: 34 years) and who had completed ≥1 follow-up questionnaire (sent every 6 months). Occupational use of high-level disinfectants (HLDs) was evaluated by questionnaire. We examined the association between HLD use and asthma development, adjusted for age, race, ethnicity, smoking status and body mass index.During 67?392 person-years of follow-up, 391 nurses reported incident clinician-diagnosed asthma. Compared with nurses who reported ≤5 years of HLD use (89%), those with 5 years of HLD use (11%) had increased risk of incident asthma (adjusted HR (95%?CI), 1.39 (1.04 to 1.86)). The risk of incident asthma was elevated but not statistically significant in those reporting 5 years of HLD use and current use of ≥2 products (1.72 (0.88 to 3.34)); asthma risk was significantly elevated in women with 5 years of HLD use but no current use (1.46 (1.00 to 2.12)).Occupational use of HLDs was prospectively associated with increased asthma incidence in early- to mid-career nurses.
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