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首页> 外文期刊>Reproductive sciences >T-206 PD-1/PD-L1 Expression of Peripheral Blood Th1, Thl7 and Treg Cells in Women with Unexplained Recurrent Pregnancy Loss.
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T-206 PD-1/PD-L1 Expression of Peripheral Blood Th1, Thl7 and Treg Cells in Women with Unexplained Recurrent Pregnancy Loss.

机译：T-206 PD-1 / PD-L1外周血TH1，THL7和TH17和TREG细胞的表达，具有无法解释的复发性妊娠损失。

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Introduction: The interaction between programmed cell death-1 (PD-1, CD279) and its ligand PD-L1 (CD274) has been reported to be involved in the establishment of maternal-fetal tolerance and the maintenance of pregnancy, by regulating T-cell homeostasis via suppressing self-reactive immune effectors. Blockade of this pathway, by anti-PD1 or anti-PD-L1, results in diminished Tregs function, increased T cell accumulation and proliferation, dysregulated T cell homeostasis, and disturbance of the delicate balance between tolerance and immunity at the maternal-fetal interface. Methods: Aprospective cohort study was performed. Forty-five women with 2 or more RPL of unknown etiology and 20 fertile women who had at least one or more live-born infants were enrolled from Jan 2017 to Jul 2019. The expression of PD-1/PD-L1 on CD4+ T cells in the peripheral blood, including Th1, Th17, and Treg cells were analyzed by flow cytometry. Results: The proportion of PD-1+ Th1 (CD4+/IFN-γ+/CD279+ and CD4+/TNF-α+/CD279+) and Th17 cells (CD4+/IL17+/CD279+) were significantly lower in RPL group than those of controls (P<0.05, respectively). The proportion of PD-1+Tregs (CD4+/CD25+/CD127dim/-/ CD279+) was not different between the two groups. The proportion of PD-L1+ Th17 cells was significantly lower (CD4+IL17+CD274+) in the RPL group as compared with that of normal controls (P<0.05). However, the proportions of PD-L1+ Th1 (CD4+/IFN-γ+/CD274+ and CD4+/ TNF-α+/CD274+), and Treg (CD4+/CD25+/CD127dim/-/CD274+) cells were not different between the RPL group and fertile controls (P>0.05, respectively). In Th1, Th17 and Treg cells, the proportions of PD-L1+ (CD274+) cells were significantly higher than those of PD-1+ (CD279+) cells in both RPL group and controls (P<0.05, respectively). Area under the curve analysis revealed that the best diagnostic performance was the combined expression of PD-1 and PD-La on Th17 cells which had AUC 0.84 (CD 0.73-0.95, sensitivity 0.68, specificity 0.98). Conclusion: Decreased expression of PD-1/PD-L1 on Th17 cells as well as decreased expression of PD-1 on Th1 cells may lead to enhanced Th17 and Th1 immunity and result in the imbalance between Th17, Th1 and Treg cells in women with RPL. Further studies are needed to confirm this finding.
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