Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice

Wang Q.; Tan Q. Y.; Xu W.; Qi H. B.; Chen D.; Zhou S.; Ni Z. H.; Kuang L.; Guo J. Y.; Huang J. L.; Wang X. X.; Wang Z. Q.; Su N.; Chen B.; Jiang W. L.; Gao Y.; Chen H. G.; Du X. L.; Xie Y. L.; Chen L.

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Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice

机译：Cartilage特异性缺失Alk5基因导致小鼠的渐进性骨关节炎状表型

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摘要

Objective: Previous studies have shown that Transforming growth factor-beta (TGF-beta)/TGF beta RII-Smad3 signaling is involved in articular cartilage homeostasis. However, the role of TGF-beta/ALK5 signaling in articular cartilage homeostasis has not been fully defined. In this study, a combination of in vitro and in vivo approaches was used to elucidate the role of ALK5 signaling in articular cartilage homeostasis and the development of osteoarthritis (OA).

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来源
《Osteoarthritis and cartilage》 |2017年第11期|共12页
作者
Wang Q.; Tan Q. Y.; Xu W.; Qi H. B.; Chen D.; Zhou S.; Ni Z. H.; Kuang L.; Guo J. Y.; Huang J. L.; Wang X. X.; Wang Z. Q.; Su N.; Chen B.; Jiang W. L.; Gao Y.; Chen H. G.; Du X. L.; Xie Y. L.; Chen L.;
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作者单位

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Rush Univ Med Ctr Dept Biochem Chicago IL 60612 USA;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

Third Mil Med Univ Res Inst Surg Daping Hosp Trauma Ctr Dept Rehabil Med Ctr Bone Metab &

Repair;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Osteoarthritis; Chondrocytes; ALK5; PRG4; CREB;

机译：骨关节炎;软骨细胞;ALK5;PRG4;CREB;

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4. Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice [J] . Wang Q., Tan Q. Y., Xu W., Osteoarthritis and cartilage . 2017,第11期

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9. Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice [O] . Q. Wang, Q.Y. Tan, W. Xu, -1

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机译：来自辐射和对照小鼠的肺腺癌中的Rb和p53基因缺失

Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice

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