The histopathology of SPINK1-associated chronic pancreatitis

Jones Terrell E.; Bellin Melena D.; Yadav Dhiraj; Freeman Martin L.; Schwarzenberg Sarah J.; Slivka Adam; Chennat Jennifer S.; Beilman Gregory J.; Chinnakotla Srinath; Pruett Timothy L.; Kirchner Varvara; Humar Abhinav; Wijkstrom Martin; Zureikat Amer H.; Nikiforova Marina N.; Wald Abigail I; Whitcomb David C.; Singhi Aatur D.

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The histopathology of SPINK1-associated chronic pancreatitis

机译：Spink1相关慢性胰腺炎的组织病理学

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Background: The identification of genetic risk factors for chronic pancreatitis, such as PRSS1, CFTR and SPINK1, provides the opportunity to define key pathologic hallmarks and etiologic-specific changes. For example, pancreata from PRSS1 and CFTR patients exhibit progressive lipomatous atrophy without significant fibrosis. Considering the pathology of SPINK1-associated pancreatitis is ill-defined, we examined the pancreata of SPINK1 patients with chronic pancreatitis.

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来源
《Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.]》 |2020年第8期|共8页
作者
Jones Terrell E.; Bellin Melena D.; Yadav Dhiraj; Freeman Martin L.; Schwarzenberg Sarah J.; Slivka Adam; Chennat Jennifer S.; Beilman Gregory J.; Chinnakotla Srinath; Pruett Timothy L.; Kirchner Varvara; Humar Abhinav; Wijkstrom Martin; Zureikat Amer H.; Nikiforova Marina N.; Wald Abigail I; Whitcomb David C.; Singhi Aatur D.;
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作者单位

Univ Pittsburgh Med Ctr Dept Pathol Pittsburgh PA USA;

Univ Minnesota Sch Med Dept Pediat Minneapolis MN 55455 USA;

Univ Pittsburgh Med Ctr Dept Med Pittsburgh PA USA;

Univ Minnesota Sch Med Dept Med Minneapolis MN 55455 USA;

Univ Minnesota Sch Med Dept Pediat Minneapolis MN 55455 USA;

Univ Pittsburgh Med Ctr Dept Med Pittsburgh PA USA;

Univ Pittsburgh Med Ctr Dept Med Pittsburgh PA USA;

Univ Minnesota Sch Med Dept Surg Minneapolis MN 55455 USA;

Univ Minnesota Sch Med Dept Surg Minneapolis MN 55455 USA;

Univ Minnesota Sch Med Dept Surg Minneapolis MN 55455 USA;

Univ Minnesota Sch Med Dept Surg Minneapolis MN 55455 USA;

Univ Pittsburgh Med Ctr Dept Surg Pittsburgh PA USA;

Univ Pittsburgh Med Ctr Dept Surg Pittsburgh PA USA;

Univ Pittsburgh Med Ctr Dept Surg Pittsburgh PA USA;

Univ Pittsburgh Med Ctr Dept Pathol Pittsburgh PA USA;

Univ Pittsburgh Med Ctr Dept Pathol Pittsburgh PA USA;

Univ Pittsburgh Med Ctr Dept Med Pittsburgh PA USA;

Univ Pittsburgh Med Ctr Dept Pathol Pittsburgh PA USA;

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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Alcohol; Fibrosis; Pancreatitis; Genetics; Pathology;

机译：酒精;纤维化;胰腺炎;遗传学;病理学;

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1. Novel mutation and polymorphism of PRSS1 gene in the Chinese patients with hereditary pancreatitis and chronic pancreatitis [J] . LIU Qi-cai, GAO Feng, OU Qi-shui, 中华医学杂志（英文版） . 2008,第002期
2. Guidelines on the histopathology of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and the European Pancreatic Club [J] . Esposito Irene, Hruban Ralph H., Verbeke Caroline, Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] . 2020,第4期

机译：慢性胰腺炎组织病理学指南。与国际胰腺胰腺炎，美国胰腺协会，日本胰腺社会和欧洲胰俱乐部合作，慢性胰腺炎的工作组工作组的建议
3. Diagnostic Performance of Endoscopic Ultrasound (EUS) for Non-Calcific Chronic Pancreatitis (NCCP) Based on Histopathology [J] . Trikudanathan Guru, Vega-Peralta Jose, Malli Ahmad, The American Journal of Gastroenterology . 2016,第4期

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4. Diagnostic Performance of Contrast-Enhanced MRI With Secretin-Stimulated MRCP for Non-Calcific Chronic Pancreatitis: A Comparison With Histopathology [J] . Trikudanathan Guru, Walker Sidney P., Munigala Satish, The American Journal of Gastroenterology . 2015,第11期

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5. Feature Classification and Analysis of Acute and Chronic Pancreatitis Using Supervised Machine Learning Algorithm [C] . R. Balakrishna, R. Anandan International Conference on Research in Intelligent and Computing in Engineering . 2020

机译：利用监督机学习算法特征分类和分析急性和慢性胰腺炎
6. Health care providers' use of patient education materials for chronic pancreatitis patients. [D] . Brown, Erica Lynn Blender. 2009

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7. A phase 1/2 trial to evaluate the pharmacokinetics safety and efficacy of NI-03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC) [O] . Mitchell L. Ramsey, Janet Nuttall, Phil A. Hart 2019

机译：1/2期临床试验用于评估NI-03在慢性胰腺炎患者中的药代动力学安全性和有效性：一项关于评估慢性胰腺炎中的稳压器治疗的随机对照试验的研究方案（TACTIC）
8. Pancreas disease.Advances in diagnosis and treatment.2.Chronic pancreatitis.3.Medical treatment and prognosis of chronic pancreatitis.3.Endoscopic treatment of chronic pancreatitis. [O] . 1992

机译：胰腺疾病。诊断和治疗的进展.2。慢性胰腺炎的医学治疗与预后.3。慢性胰腺炎的诊断治疗。
9. Transgenic Animal Model for Chronic Pancreatitis. [R] . Archer, H., Bar-Sagi, D. 2004

机译：慢性胰腺炎的转基因动物模型。

The histopathology of SPINK1-associated chronic pancreatitis

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