Experimental pancreatitis is characterized by rapid T cell activation, Th2 differentiation that parallels disease severity, and improvement after CD4(+) T cell depletion

Glaubitz Juliane; Wilden Anika; van den Brandt Cindy; Weiss Frank U.; Broeker Barbara M.; Mayerle Julia; Lerch Markus M.; Sendler Matthias

首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Experimental pancreatitis is characterized by rapid T cell activation, Th2 differentiation that parallels disease severity, and improvement after CD4(+) T cell depletion

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Experimental pancreatitis is characterized by rapid T cell activation, Th2 differentiation that parallels disease severity, and improvement after CD4(+) T cell depletion

机译：实验性胰腺炎的特点是T细胞活化快速，Th2分化，使疾病严重程度平衡，以及CD4（+）T细胞耗尽后的改善

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Background: Acute pancreatitis is a gastrointestinal disorder of high incidence resulting in life threatening complications in up to 20% of patients. Its severe form is characterized by an extensive and systemic immune response. We investigated the role of the adaptive immune response in two experimental models of pancreatitis.

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来源
《Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.]》 |2020年第8期|共11页
作者
Glaubitz Juliane; Wilden Anika; van den Brandt Cindy; Weiss Frank U.; Broeker Barbara M.; Mayerle Julia; Lerch Markus M.; Sendler Matthias;
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作者单位

Ernst Moritz Arndt Univ Greifswald Univ Med Dept Med A Greifswald Germany;

Ernst Moritz Arndt Univ Greifswald Univ Med Dept Med A Greifswald Germany;

Ernst Moritz Arndt Univ Greifswald Univ Med Dept Med A Greifswald Germany;

Ernst Moritz Arndt Univ Greifswald Univ Med Dept Med A Greifswald Germany;

Univ Med Inst Immunol &

Transfus Med Dept Immunol Greifswald Germany;

Ernst Moritz Arndt Univ Greifswald Univ Med Dept Med A Greifswald Germany;

Ernst Moritz Arndt Univ Greifswald Univ Med Dept Med A Greifswald Germany;

Ernst Moritz Arndt Univ Greifswald Univ Med Dept Med A Greifswald Germany;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
CD4+T-cells; Acute pancreatitis; Inflammation;

机译：CD4 + T细胞;急性胰腺炎;炎症;

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1. Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differentiation [J] . Iva Xhangolli, Burak Dura, GeeHee Lee, 基因组蛋白质组与生物信息学报（英文版） . 2019,第002期
2. Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis [J] . Inmaculada, Lopez-Font, Sabrina, 世界胃肠病学杂志：英文版 . 2010,第027期
3. Suppression of Early IL-4 Production Underlies the Failure of CD4 T Cells Activated by TLR-Stimulated Dendritic Cells to Differentiate into Th2 Cells [J] . Jie Sun, Edward J. Pearce The journal of immunology . 2007,第3期

机译：抑制早期IL-4产生是TLR刺激的树突状细胞激活的CD4 T细胞分化为Th2细胞的失败的基础。
4. Suppression of Early IL-4 Production Underlies the Failure of CD4 T Cells Activated by TLR-Stimulated Dendritic Cells to Differentiate into Th2 Cells. [J] . Sun J, Pearce EJ The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第3期

机译：早期IL-4产生的抑制是TLR刺激的树突状细胞激活的CD4 T细胞分化为Th2细胞的失败的基础。
5. Pro-inflammation and Anti-inflammation During Severe Acute Pancreatitis Develop in Parallel and Result in Misbalanced T-cell Activation Which Increases Disease Severity [J] . Sendler M., Wilden A., Glaubitz J., Pancreas . 2019,第10期

机译：严重急性胰腺炎的促炎和抗炎并行发展，导致错误的T细胞活化，增加疾病严重程度
6. Expression of GATA-3, c-Maf and Helios transcription factor mRNA by CD4 T cells responding to Th2 antigen in vivo [C] . Serre K., Mohr E., Toellner K.M., European Congress of Immunology . 2009

机译：CD4 T细胞在体内响应Th2抗原的CD4 T细胞表达GATA-3，C-MAF和HELIOS转录因子mRNA
7. B cells with aberrant activation of Notch1 signaling promote Treg and Th2 cell-dominant T cell responses via IL-33 [D] . Arima, Hiroshi 2019

机译：Notch1信号异常激活的B细胞通过IL-33促进Treg和Th2细胞主导的T细胞反应
8. Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis [O] . Ali A. Aghdassi, Daniel S. John, Matthias Sendler, 2018

机译：组织蛋白酶D在实验性胰腺炎期间主要在炎症细胞中调节组织蛋白酶B的活化和疾病的严重程度
9. Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis [O] . Ali A. Aghdassi, Daniel S. John, Matthias Sendler, 2018

机译：组织蛋白酶D在实验胰腺炎期间主要在炎症细胞中调节组织蛋白酶B活化和疾病严重程度
10. CD28 Activation Promotes Th2 Subset Differentiation by Human CD4(+) Cells [R] . King, C. L., Stupi, R. J., Craighead, N., 1995

机译：CD28活化促进人CD4（+）细胞的Th2亚组分化

Experimental pancreatitis is characterized by rapid T cell activation, Th2 differentiation that parallels disease severity, and improvement after CD4(+) T cell depletion

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