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首页> 外文期刊>Parasitology >Distinct hepatic myeloid and lymphoid cell repertoires are associated with susceptibility and resistance to Ascoris infection
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Distinct hepatic myeloid and lymphoid cell repertoires are associated with susceptibility and resistance to Ascoris infection

机译：明显的肝脏骨髓和淋巴细胞曲目与易感性和抗性感染有关

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摘要

The soil-transmitted helminth Ascaris lumbricoides infects ~800 million people worldwide. Some people are heavily infected, harbouring many worms, whereas others are only lightly infected. The mechanisms behind this difference are unknown. We used a mouse model of hepatic resistance to Ascaris, with C57BL/6J mice as a model for heavy infection and CBA/Ca mice as a model for light infection. The mice were infected with the porcine ascarid, Ascaris suum or the human ascarid, A. lumbricoides and immune cells in their livers and spleens were enumerated using flow cytometry. Compared to uninfected C57BL/6J mice, uninfected CBA/Ca mice had higher splenic CD4+ and yd T cell counts and lower hepatic eosinophil, Kupffer cell and B cell counts. Infection with A. suum led to expansions of eosinophils, Kupffer cells, monocytes and dendritic cells in the livers of both mouse strains and depletions of hepatic natural killer (NK) cells in CBA/Ca mice only. Infection with A. lumbricoides led to expansions of hepatic eosinophils, monocytes and dendritic cells and depletions of CD8+, afi, NK and NK T cells in CBA/Ca mice, but not in C57BL/6J mice where only monocytes expanded. Thus, susceptibility and resistance to Ascaris infection are governed, in part, by the hepatic immune system.
机译：土壤传播的蛔虫感染全球约8亿人。有些人感染严重，藏有许多蠕虫，而另一些人只是轻微感染。这种差异背后的机制尚不清楚。我们使用小鼠蛔虫肝抵抗模型，C57BL/6J小鼠作为重度感染模型，CBA/Ca小鼠作为轻度感染模型。用猪蛔虫、猪蛔虫或人蛔虫感染小鼠，用流式细胞术计数小鼠肝脏和脾脏中的免疫细胞。与未感染的C57BL/6J小鼠相比，未感染的CBA/Ca小鼠脾脏CD4+和yd T细胞计数较高，肝脏嗜酸性粒细胞、库普弗细胞和B细胞计数较低。感染苏木弧菌后，两种小鼠品系的肝脏中的嗜酸性粒细胞、库普弗细胞、单核细胞和树突状细胞均出现扩增，仅CBA/Ca小鼠的肝脏自然杀伤细胞（NK）细胞减少。在CBA/Ca小鼠中，蛔虫感染导致肝嗜酸性粒细胞、单核细胞和树突状细胞的扩增，以及CD8+、afi、NK和NK T细胞的消耗，但在C57BL/6J小鼠中，只有单核细胞扩增。因此，对蛔虫感染的易感性和耐药性部分由肝脏免疫系统控制。

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  • 来源
    《Parasitology》 |2021年第5期|共11页
  • 作者

    Gwendoline Deslyper;

  • 作者单位

    Department of Zoology School of Natural Sciences Trinity College Dublin Dublin Ireland;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 寄生虫病;
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