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首页> 外文期刊>Parasitology >Determination of lumefantrine as an effective drug against Toxoplasma gondii infection - in vitro and in vivo study
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Determination of lumefantrine as an effective drug against Toxoplasma gondii infection - in vitro and in vivo study

机译：测定Lumefantrine作为一种有效药物对弓形虫感染的有效药物 - 体外和体内研究

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Toxoplasma gondii is an obligate intracellular protozoan parasite, which can infect almost all warm-blooded animals, including humans, leading to toxoplasmosis. Currently, the effective treatment for human toxoplasmosis is the combination of sulphadiazine and pyrimethamine. However, both drugs have serious side-effects and toxicity in the host. Therefore, there is an urgent need for the discovery of new anti-T. gondii drugs with high potency and less or no side-effects. Our findings suggest that lumefantrine exerts activity against T. gondii by inhibiting its proliferation in Vero cells in vitro without being toxic to Vero cells (P ≤ 0.01). Lumefantrine prolonged mice infected with T. gondii from death for 3 days at the concentration of 50 μg L?1 than negative control (phosphate-buffered saline treated only), and reduced the parasite burden in mouse tissues in vivo (P ≤ 0.01; P ≤ 0.05). In addition, a significant increase in interferon gamma (IFN-γ) production was observed in high-dose lumefantrine-treated mice (P ≤ 0.01), whereas interleukin 10 (IL-10) and IL-4 levels increased in low-dose lumefantrine-treated mice (P ≤ 0.01). The results demonstrated that lumefantrine may be a promising agent to treat toxoplasmosis, and more experiments on the protective mechanism of lumefantrine should be undertaken in further studies.
机译：弓形虫是一种专性细胞内原生动物寄生虫，可感染几乎所有温血动物，包括人类，导致弓形虫病。目前，磺胺嘧啶和乙胺嘧啶联合使用是治疗人类弓形虫病的有效方法。然而，这两种药物在宿主体内都有严重的副作用和毒性。因此，迫切需要发现高效、副作用少或无副作用的新型抗弓形虫药物。我们的研究结果表明，羽扇豆碱通过抑制弓形虫在体外Vero细胞中的增殖而对Vero细胞没有毒性（P≤ 0.01). 在浓度为50μg L？的情况下，Lumefantrine使感染弓形虫的小鼠死亡时间延长了3天？1比阴性对照组（仅经磷酸盐缓冲盐水处理）减少了体内小鼠组织中的寄生虫负担（P≤ 0.01; P≤ 0.05). 此外，在高剂量苯丙胺治疗的小鼠中观察到γ干扰素（IFN-γ）的产生显著增加（P≤ 0.01），而白细胞介素10（IL-10）和白细胞介素4水平在低剂量苯丙胺治疗的小鼠中升高（P≤ 0.01). 结果表明，羽扇豆素可能是治疗弓形虫病的一种有前途的药物，关于羽扇豆素的保护机制有待进一步研究。

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