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首页> 外文期刊>Parasitology >Therapeutic efficacy of mebendazole and artemisinin in different phases of trichinellosis: a comparative experimental study
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Therapeutic efficacy of mebendazole and artemisinin in different phases of trichinellosis: a comparative experimental study

机译：梅白唑和青蒿素在粒细胞中不同阶段的治疗疗效：比较实验研究

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摘要

The present work aimed at studying the efficacy of mebendazole (MBZ) compared to artemisinin (ART) for the treatment of trichinellosis at various phases of infection. Seventy Swiss albino mice were orally infected by 300 Trichinella spiralis (T. spiralis) larvae. Mice were divided into infected untreated control group and infected groups treated with 50mgkg~' MBZ and 300 mg kg"1 ART for three and five consecutive days, respectively, at the enteral phase [2-4 days post infection (PI)], invasive phase (10-12 days PI) and encapsulated phase (28-30 days PI). All mice were sacrificed 35-42 days PI. MBZ and ART revealed a significant decrease in mean larval counts and increase of larval per cent reduction (LR %) when treatment was initiated during the enteral phase compared to the other phases. MBZ showed significantly higher LR % (99.7, 83.95 and 89.65%) than ART (80.58, 67.0 and 79.2%) when administered at the three infection phases. Histopathological study showed a decrease in the number of encysted larvae, their surrounding cellular infiltrates and increased regenerative muscles in all treated mice. In conclusion, ART possesses a substantial anthel-mintic activity against T. spiralis infection in mice both at the enteral and encapsulated phases, yet, significantly lower than MBZ.
机译：本研究旨在研究甲苯咪唑（MBZ）与青蒿素（ART）在不同感染阶段治疗旋毛虫病的疗效。70只瑞士白化小鼠经口感染了300只旋毛虫幼虫。将小鼠分为感染对照组和感染组，分别在肠道期[2-4天感染后（PI）]、侵入期（10-12天PI）和包膜期（28-30天PI）连续3天和5天给予50mgkg ~'MBZ和300mg kg“1 ART治疗.所有小鼠于35-42天处死。MBZ和ART显示，与其他阶段相比，在肠道阶段开始治疗时，平均幼虫数量显著减少，幼虫减少百分比（LR%）增加。在三个感染阶段，MBZ的LR（99.7%、83.95%和89.65%）显著高于ART（80.58%、67.0%和79.2%）。组织病理学研究显示，在所有治疗小鼠中，包囊幼虫数量减少，周围细胞浸润，再生肌肉增加。综上所述，ART在小鼠肠内和包膜期对旋毛虫感染具有显著的驱虫活性，但显著低于MBZ。

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  • 来源
    《Parasitology》 |2021年第5期|共6页
  • 作者

    Amal Farahat Allam;

  • 作者单位

    Medical Research Institute University of Alexandria Department Alexandria Egypt;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 寄生虫病;
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