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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Microbiome and Cervical Cancer
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Microbiome and Cervical Cancer

机译：微生物组和宫颈癌

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摘要

Persistent infection with some types of mucosal human papillomavirus (HPV) is the etiological factor for the development of cervical cancer and its precursor lesions. Besides, several cofactors are known to play a role in cervical disease onset and progression either by favoring or by preventing HPV infection and persistence. The microbiome of a healthy female genital tract is characterized by the presence of 1 or few varieties of lactobacilli. However, high-throughput studies addressing the bacterial diversity and abundance in the female genital tract have shown that several factors, including hormonal levels, hygiene habits, and sexually transmitted diseases may disrupt the natural balance, favoring the outgrowth of some groups of bacteria, which in turn may favor some pathological states. Recently, the vaginal microbiome has emerged as a new variable that could greatly influence the natural history of HPV infections and their clinical impact. In this context, changes in the vaginal microbiome have been detected in women infected with HPV and women with HPV-associated lesions and cancer. However, the role of specific bacteria groups in the development/progression or prevention/regression of HPV-associated pathologies is not well understood. In this review we summarize the current knowledge concerning changes in vaginal microbiome and cervical disease. We discuss the potential functional interplay between specific bacterial groups and HPV infection outcomes.
机译：持续感染某些类型的粘膜人乳头瘤病毒（HPV）是宫颈癌及其前体病变发展的病因。此外，已知有几种辅助因子通过支持或预防HPV感染和持续性在宫颈疾病的发病和进展中发挥作用。健康女性生殖道的微生物群的特征是存在1种或几种乳酸杆菌。然而，针对女性生殖道细菌多样性和丰度的高通量研究表明，激素水平、卫生习惯和性传播疾病等多种因素可能会破坏自然平衡，有利于某些细菌群的生长，进而有利于某些病理状态。最近，阴道微生物组成为一个新的变量，可能会极大地影响HPV感染的自然史及其临床影响。在这种情况下，已在感染HPV的女性以及患有HPV相关病变和癌症的女性中检测到阴道微生物组的变化。然而，特定菌群在HPV相关疾病的发展/进展或预防/消退中的作用尚不清楚。在这篇综述中，我们总结了目前有关阴道微生物群变化和宫颈疾病的知识。我们讨论了特定细菌群与HPV感染结果之间潜在的功能相互作用。

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