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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis
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The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis

机译：Fusobacterium成核在结肠直肠癌中的作用

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摘要

Colorectal cancer (CRC) is one of the most frequent and deadly neoplasms worldwide. Genetic factors, lifestyle habits, and inflammation are important risk factors associated with CRC development. In recent years, growing evidence has supporting the significant role of the intestinal microbiome in CRC carcinogenesis. Disturbances in the healthy microbial balance, known as dysbiosis, are frequently observed in these patients. Pathogenic microorganisms that induce intestinal dysbiosis have become an important target to determine the role of bacterial infection in tumorigenesis. Interestingly, the presence of different bacterial strains, such as Fusobacterium nucleatum, has been detected in tissue and stool from patients with CRC and associated with substantial clinical and molecular features, as well as with patient therapy response. Therefore, understanding how the presence and levels of F. nucleatumstrains in the gut affect the risk of CRC onset and progression may inform suitable candidates for interventions focused on modulation of this bacteria. Here we review new insights into the role of gut microbiota in CRC carcinogenesis and the clinical utility of using the detection of F. nucleatum in different settings such as screening, prognosis, and microbiota modulation as a means to prevent cancer, augment therapies, and reduce adverse effects of treatment.
机译：结直肠癌（CRC）是世界上最常见、最致命的肿瘤之一。遗传因素、生活习惯和炎症是与大肠癌发生相关的重要风险因素。近年来，越来越多的证据支持肠道微生物群在大肠癌发生中的重要作用。在这些患者中经常观察到健康微生物平衡紊乱，称为失调。引起肠道失调的病原微生物已成为确定细菌感染在肿瘤发生中作用的重要靶点。有趣的是，在结直肠癌患者的组织和粪便中检测到不同菌株的存在，如有核梭杆菌，并与大量临床和分子特征以及患者治疗反应有关。因此，了解肠道中有核梭状芽胞杆菌菌株的存在和水平如何影响结直肠癌发病和进展的风险，可能有助于选择合适的干预措施，重点是调节这种细菌。在这里，我们回顾了肠道微生物群在大肠癌发生中的作用的新见解，以及在筛查、预后和微生物群调节等不同情况下检测有核梭状芽胞杆菌作为预防癌症、增强治疗和减少治疗副作用的手段的临床应用。

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