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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Immune System Efficiency in Cancer and the Microbiota Influence
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Immune System Efficiency in Cancer and the Microbiota Influence

机译：免疫系统癌症和微生物群的影响

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The immune system plays a critical role in preventing cancer development and progression. However, the complex network of cells and soluble factor that form the tumor microenvironment (TME) can dictate the differentiation of tumor-infiltrating leukocytes and shift the antitumor immune response into promoting tumor growth. With the advent of cancer immunotherapy, there has been a reinvigorated interest in defining how the TME shapes the antitumor immune response. This interest brought to light the microbiome as a novel player in shaping cancer immunosurveillance. Indeed, accumulating evidence now suggests that the microbiome may confer susceptibility or resistance to certain cancers and may influence response to therapeutics, particularly immune checkpoint inhibitors. As we move forward into the age of precision medicine, it is vital that we define the factors that influence the interplay between the triad immune system-microbiota-cancer. This knowledge will contribute to improve the therapeutic response to current approaches and will unravel novel targets for immunotherapy.
机译：免疫系统在预防癌症发展和进展中起着关键作用。然而，形成肿瘤微环境（TME）的细胞和可溶性因子的复杂网络可以决定肿瘤浸润性白细胞的分化，并将抗肿瘤免疫反应转变为促进肿瘤生长。随着癌症免疫治疗的出现，定义TME如何形成抗肿瘤免疫反应的兴趣重新燃起。这种兴趣使微生物组成为塑造癌症免疫监测的新角色。事实上，越来越多的证据表明，这种微生物群可能会对某些癌症产生易感性或耐药性，并可能影响对治疗的反应，尤其是免疫检查点抑制剂。随着我们进入精确医学时代，定义影响三联免疫系统微生物群与癌症之间相互作用的因素至关重要。这些知识将有助于改善对当前方法的治疗反应，并将揭示免疫治疗的新靶点。

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