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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses
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Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses

机译：合成天然酮在恒河猴中的增强效果：剂量 - 反应和行为经济分析

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The abuse of synthetic cathinones ("bath salts") with psychomotor stimulant and/or entactogenic properties emerged as a public health concern when they were introduced as "legal" alternatives to drugs of abuse such as cocaine or MDMA. In this study, experiments were conducted in nonhuman primates to examine how differences in transporter selectivity might impact the reinforcing effects of synthetic cathinones. Rhesus monkeys (N = 5) were trained to respond for intravenous injections under a fixed-ratio (FR) 30, timeout 60-s schedule of reinforcement. The reinforcing effects of selected cathinones (e.g., MDPV, alpha PVP, MCAT, and methylone) with a range of pharmacological effects at dopamine and serotonin transporters were compared to cocaine and MDMA using dose-response analysis under a simple FR schedule and behavioral economic procedures that generated demand curves for two doses of each drug. Results show that one or more doses of all drugs were readily self-administered in each subject and, excepting MDMA (21 injections/session), peak levels of self-administration were similar across drugs (between 30 and 40 injections/session). Demand elasticity for the peak and the peak + 1/2-log dose of each drug did not significantly differ, and when data for the two doses were averaged for each drug, the following rank-order of reinforcing strength emerged: cocaine > MCAT = MDPV = methylone > alpha PVP = MDMA. These results indicate that the reinforcing strength of synthetic cathinones are not related to their selectivity in binding dopamine or serotonin transporter sites.
机译：当合成卡西酮（“浴盐”）作为可卡因或二亚甲基双氧苯丙胺等滥用药物的“合法”替代品被引入时，具有精神运动兴奋剂和/或致内生肌体特性的合成卡西酮（“浴盐”）的滥用成为一个公共卫生问题。在这项研究中，在非人灵长类动物中进行了实验，以研究转运体选择性的差异如何影响合成卡西酮的增强效应。训练恒河猴（N=5）在固定比率（FR）30、超时60-s强化计划下对静脉注射作出反应。在一个简单的FR计划和行为经济程序下，通过剂量反应分析，将选定的卡西酮（如MDPV、α-PVP、MCAT和甲酮）在多巴胺和5-羟色胺转运体的一系列药理作用与可卡因和MDMA进行了比较，得出了每种药物两剂的需求曲线。结果表明，每名受试者均可自行服用一剂或多剂所有药物，除MDMA（21次注射/疗程）外，各药物的自行服用峰值水平相似（30至40次注射/疗程）。每种药物的峰值和峰值+1/2对数剂量的需求弹性没有显著差异，当对每种药物的两种剂量的数据进行平均时，出现了以下增强强度的排名顺序：可卡因>MCAT=MDPV=甲酮>α-PVP=MDMA。这些结果表明，合成卡西酮的增强强度与其结合多巴胺或5-羟色胺转运体位点的选择性无关。

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