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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Appetitive, antinociceptive, and hypothermic effects of vaped and injected Delta-9-tetrahydrocannabinol (THC) in rats: exposure and dose-effect comparisons by strain and sex
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Appetitive, antinociceptive, and hypothermic effects of vaped and injected Delta-9-tetrahydrocannabinol (THC) in rats: exposure and dose-effect comparisons by strain and sex

机译：在大鼠中蒸发和注射δ-9-四氢尼酚（THC）的表现，抗血质双层和低温效应：菌株和性别的暴露和剂量效应比较

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Advances in drug vapor exposure systems have enabled evaluation of Delta -9-tetrahydrocannabinol (THC) vapor effects in laboratory animals. The purpose of this study was to 1) establish a range of parameters of THC vapor exposure in rats sufficient to produce a behavioral dose-effect curve in a battery of tasks sensitive to THC; and 2) to investigate sex differences in the effects of THC vapor exposure and THC injection (intraperitoneal, IP) on these behaviors in two strains of outbred rats. Male and female Sprague Dawley and Wistar rats (N = 22, 5-6/sex per group) received THC via passive vapor exposure (200 mg/mL; 5 conditions) and IP injection (1-20 mg/kg) in a within subject design. The effects of vaped and injected THC on appetite was determined using progressive ratio responding for food pellets. THC effects on nociception, measured using the tail withdrawal assay, and body temperature were also assessed during a 5-h test period for evaluation of time course of effects. Plasma THC concentrations were assessed after THC vapor and 10 mg/kg IP THC. THC vapor produced exposure-related increases and decreases in motivation to obtain food under the progressive ratio schedule. IP THC (3-20 mg/ kg) reduced breakpoints. Vaped and injected THC produced exposure and dose-dependent antinociception and hypothermia. Sex and strain differences in THC effects were also observed. Plasma THC concentrations were higher after 10 mg/kg IP THC (152 ng/mL) compared to the highest vapor exposure condition tested (38 ng/mL), but magnitude of behavioral effects were comparable. THC vapor exposure produced reliable, dose orderly effects on food-maintained behavior, nociception, and body temperature that are comparable to effects of IP THC, although there were differences in the time course of behavioral outcomes.
机译：药物蒸气暴露系统的进展使我们能够在实验动物中评估δ-9-四氢大麻酚（THC）蒸气效应。本研究的目的是1）建立大鼠THC蒸汽暴露的一系列参数，足以在对THC敏感的一系列任务中产生行为剂量效应曲线；2）研究THC蒸汽暴露和THC注射（腹腔内注射，IP）对两个品系的远交大鼠这些行为的影响的性别差异。雄性和雌性Sprague Dawley和Wistar大鼠（N=22，每组5-6只/性别）在受试者内设计中通过被动蒸汽暴露（200 mg/mL；5种条件）和IP注射（1-20 mg/kg）接受THC。VAED和注射THC对食欲的影响通过对食物颗粒的累进比率反应来确定。在5小时的试验期内，还评估了THC对伤害性感觉的影响（使用尾部戒断试验进行测量）和体温，以评估影响的时间过程。在THC蒸汽和10mg/kg的IP THC后评估血浆THC浓度。THC蒸汽产生的暴露相关的增加和减少在累进比例计划下获取食物的动机。IP THC（3-20 mg/kg）减少了断点。VAED和注射THC产生暴露和剂量依赖性抗伤害和低温。还观察到THC效应的性别和品系差异。与最高蒸汽暴露条件（38 ng/mL）相比，10 mg/kg IP THC（152 ng/mL）后的血浆THC浓度更高，但行为影响的程度相当。THC蒸汽暴露对食物维持行为、伤害感受和体温产生了可靠的、剂量有序的影响，与IP THC的影响相当，尽管在行为结果的时间过程中存在差异。

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