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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Sex differences in the elevated plus-maze test and large open field test in adult Wistar rats
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Sex differences in the elevated plus-maze test and large open field test in adult Wistar rats

机译：成人Wistar大鼠高架迷宫试验和大开场试验的性别差异

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There is a growing need for a better understanding of sex differences in animal models of psychiatric disorders. The elevated plus-maze (EPM) test and large open field (LOF) test are widely used to study anxiety-like behavior in rodents. Our studies explored sex differences in anxiety and activity parameters in the LOF and EPM and determined whether these parameters correlate within and between tests. Drug na?ve adult male and female Wistar rats (n = 47/sex) were used for the studies, and the rats were tested for 5 min in the EPM and 10 min in the LOF. The females spent more time on the open arms of the EPM and made more open arms entries than the males. The females also spent more time in the center zone of the LOF and made more center zone entries. The females traveled a greater distance in the LOF and EPM. There was a moderate positive correlation between time on the open arms of the EPM and time in the center zone of the LOF. There was also a moderate positive correlation between open arms entries in the EPM and center zone entries in the LOF. A hierarchical cluster analysis revealed one cluster with LOF parameters, one cluster with EPM parameters, and one cluster with parameters related to the avoidance of open spaces. In conclusion, these findings indicate that female rats display less anxiety-like behavior in the EPM and LOF. Furthermore, there are sex differences for almost all behavioral parameters in these anxiety tests.
机译：人们越来越需要更好地理解精神疾病动物模型中的性别差异。高架+迷宫（EPM）试验和大开放视野（LOF）试验被广泛用于研究啮齿类动物的焦虑样行为。我们的研究探讨了LOF和EPM中焦虑和活动参数的性别差异，并确定了这些参数在测试内部和测试之间是否相关。毒品na？ve成年雄性和雌性Wistar大鼠（n=47/性别）用于研究，大鼠在EPM中测试5分钟，在LOF中测试10分钟。与雄性相比，雌性花在EPM张开双臂上的时间更多，并且做出更多张开双臂的动作。雌性花在LOF中心区的时间也更多，进入中心区的次数也更多。雌性在LOF和EPM中移动的距离更大。EPM张开臂的时间与LOF中心区的时间呈中度正相关。EPM中的开放臂项目与LOF中的中心区项目之间也存在中度正相关。分层聚类分析显示，一个聚类具有LOF参数，一个聚类具有EPM参数，一个聚类具有与避免开放空间相关的参数。总之，这些发现表明雌性大鼠在EPM和LOF中表现出较少的焦虑样行为。此外，在这些焦虑测试中，几乎所有行为参数都存在性别差异。

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