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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Intoxication by a synthetic cannabinoid (JWH-018) causes cognitive and psychomotor impairment in recreational cannabis users
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Intoxication by a synthetic cannabinoid (JWH-018) causes cognitive and psychomotor impairment in recreational cannabis users

机译：通过合成大麻素（JWH-018）中毒地导致认知和精神运动在娱乐大麻用户中的损伤

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Background: Smoking mixtures containing synthetic cannabinoids (SCs) have become very popular over the last years but pose a serious risk for public health. Limited knowledge is, however, available regarding the acute effects of SCs on cognition and psychomotor performance. Earlier we demonstrated signs of impairment in healthy volunteers after administering one of the first SCs, JWH-018, even though subjective intoxication was low. In the current study, we aimed to investigate the acute effects of JWH-018 on several cognitive and psychomotor tasks in participants who are demonstrating representative levels of acute intoxication. Methods: 24 healthy cannabis-experienced participants took part in this placebo-controlled, cross-over study. Participants inhaled the vapor of 75 mu g JWH-018/kg body weight and were given a booster dose if needed to induce a minimum level of subjective high. They were subsequently monitored for 4 h, during which psychomotor and cognitive performance, vital signs, and subjective experience were measured, and serum concentrations were determined. Results: Maximum subjective high (average 64%) was reached 30 min after administration of JWH-018, while the maximum blood concentration was shown after 5 min (8 ng/mL). JWH-018 impaired motor coordination (CTT), attention (DAT and SST), memory (SMT), it lowered speed-accuracy efficiency (MFFT) and slowed down response speed (DAT). Conclusion: In accordance with our previous studies, we demonstrated acute psychomotor and cognitive effects of a relatively low dose of JWH-018.
机译：背景：在过去几年中，含有合成大麻素（SCs）的吸烟混合物变得非常流行，但对公众健康构成严重风险。然而，关于SCs对认知和精神运动表现的急性影响的知识有限。早些时候，我们在给健康志愿者服用第一批SCs之一JWH-018后，尽管主观中毒程度较低，但仍显示出损伤迹象。在目前的研究中，我们旨在调查JWH-018对表现出代表性急性中毒水平的参与者的几种认知和精神运动任务的急性影响。方法：24名有大麻经验的健康参与者参加了这项安慰剂对照交叉研究。参与者吸入75μg JWH-018/kg体重的蒸汽，并在需要时给予增强剂量，以诱发最低程度的主观兴奋。随后对他们进行4小时的监测，在此期间测量精神运动和认知能力、生命体征和主观体验，并测定血清浓度。结果：JWH-018给药后30min达到最大主观血药浓度（平均64%），5min后达到最大血药浓度（8ng/mL）。JWH-018损害了运动协调（CTT）、注意力（DAT和SST）、记忆（SMT），降低了速度准确性效率（MFFT）和反应速度（DAT）。结论：与我们之前的研究一致，我们证明了相对低剂量JWH-018的急性精神运动和认知效应。

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