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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Acquisition of remifentanil self-administration: Enhanced in female rats but no effect of adolescent stress exposure
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Acquisition of remifentanil self-administration: Enhanced in female rats but no effect of adolescent stress exposure

机译：收购雷芬丹尼自我管理：在女性大鼠中增强，但没有青春期压力暴露的影响

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摘要

Animal models of acquisition have been vital in shaping our understanding of vulnerability factors that influence susceptibility to drugs of abuse. Decades of research substantiates a number of biological, environmental, and behavioral factors that predict vulnerability - many of which have been important in the development of early intervention efforts in humans. The goal of the present study was to examine the acquisition of a synthetic opioid derivative in 66 adult male and female Long-Evans rats following histories of stress exposure during adolescence. Stress-exposed rats were subjected to a mild stress paradigm, which included alternating exposure to synthetic fox feces and physical restraint for eight days. Following stress induction and assessment, all rats were implanted with intravenous catheters in order to self-administer remifentanil (1 pm/kg/infusion) with no prior operant training. Acquisition of remifentanil self-administration was measured over 15 days. Findings indicate that regardless of stress condition, female rats acquired remifentanil self-administration sooner and emitted more active lever presses than males. Stress exposed animals exhibited increased anxiety-like response compared to the control group following exposure to stress, operationalized as decreased exploratory behavior on an Elevated Plus Maze. However, these effects were not expressed as significant differences in self-administration by stress. Together, these findings indicate that sex differences are evident in remifentanil self-administration.
机译：获取的动物模型对于我们理解影响药物滥用易感性的脆弱性因素至关重要。数十年的研究证实了许多预测脆弱性的生物、环境和行为因素，其中许多因素在人类早期干预工作的发展中非常重要。本研究的目的是检测66只成年雄性和雌性Long Evans大鼠在青春期有应激暴露史后获得合成阿片衍生物的情况。应激暴露的大鼠接受轻度应激模式，包括交替暴露于合成狐狸粪便和身体约束8天。在应激诱导和评估后，所有大鼠均植入静脉导管，以便在没有事先操作训练的情况下自行服用瑞芬太尼（1 pm/kg/次输注）。在15天内测量瑞芬太尼自我给药的获得情况。研究结果表明，无论应激状态如何，雌性大鼠比雄性大鼠更快地获得瑞芬太尼自我给药，并释放出更多的主动杠杆按压。与对照组相比，暴露于压力的动物在暴露于压力后表现出更高的焦虑样反应，表现为高架十字迷宫上探索行为的减少。然而，这些影响并没有表现为压力自我管理的显著差异。总之，这些发现表明，瑞芬太尼自我给药的性别差异是明显的。

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