• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >II. Antidepressants and sexual behavior: Acute fluoxetine, but not ketamine, disrupts paced mating behavior in sexually experienced female rats
【24h】

II. Antidepressants and sexual behavior: Acute fluoxetine, but not ketamine, disrupts paced mating behavior in sexually experienced female rats

机译：II。 抗抑郁药和性行为：急性氟西汀，但不是氯胺酮，破坏性经验丰富的女性大鼠的节奏交配行为

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Female sexual dysfunction is both a symptom of depression and exacerbated by treatments for depression. Ketamine, a novel treatment for depression, has been shown to enhance, whereas fluoxetine has been shown to impair sexual motivation. Sexual experience leads to more robust partner preference and paced mating behavior in female rats. Whether acute ketamine and fluoxetine similarly affect sexual motivation and mating behavior in sexually experienced female rats is unknown. Sexually experienced female rats received 10 mg/kg i.p. of ketamine or saline vehicle (Experiment 1) or 10 mg/kg i.p. of fluoxetine or water vehicle (Experiment 2) 30 min before a 10-min no-contact partner preference test followed immediately by a 15-intromission paced mating test. Partner preference and paced mating behavior did not differ between ketamineand saline-treated rats. In contrast, rats treated with fluoxetine spent significantly less time with either stimulus animal and were less active during the partner preference test than water-treated rats. Additionally, contact-return latency to ejaculation was significantly longer in fluoxetine-treated rats and they spent less time with the male during paced mating in comparison to water-treated rats. Thus, even with sexual experience, fluoxetine disrupts sexual function whereas ketamine has no detrimental effects on sexual behavior in female rats. A growing body of evidence suggests that ketamine is an encouraging new approach to treat depression particularly because it is not associated with sexual dysfunction.
机译：女性性功能障碍既是抑郁症的症状，又因抑郁症的治疗而加剧。氯胺酮是一种治疗抑郁症的新型药物，已被证明能增强性冲动，而氟西汀则被证明能削弱性冲动。性经验导致雌性大鼠更强烈的伴侣偏好和有节奏的交配行为。急性氯胺酮和氟西汀是否同样影响有性经验雌性大鼠的性动机和交配行为尚不清楚。性经验丰富的雌性大鼠在10分钟无接触伴侣偏好试验前30分钟接受10毫克/千克氯胺酮或生理盐水溶媒（实验1）或10毫克/千克氟西汀或水溶媒（实验2），然后立即进行15次内插配速交配试验。氯胺酮组和生理盐水组大鼠的伴侣偏好和交配行为没有差异。相比之下，与水处理的大鼠相比，氟西汀处理的大鼠与任何一种刺激动物待在一起的时间都显著减少，并且在伴侣偏好测试期间也不太活跃。此外，与水处理的大鼠相比，氟西汀处理的大鼠射精的接触返回潜伏期明显更长，在有节奏交配期间，它们与雄性大鼠相处的时间更少。因此，即使有过性经验，氟西汀也会破坏雌性大鼠的性功能，而氯胺酮对雌性大鼠的性行为没有有害影响。越来越多的证据表明，氯胺酮是治疗抑郁症的一种令人鼓舞的新方法，尤其是因为它与性功能障碍无关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号