Increased DNA methylation in the parvalbumin gene promoter is associated with methamphetamine dependence

Veerasakul Siriluk; Watiktinkorn Paritat; Thanoi Samur; Dalton Caroline F.; Fachim Helene A.; Nudmamud-Thanoi Sutisa; Reynolds Gavin P.

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Increased DNA methylation in the parvalbumin gene promoter is associated with methamphetamine dependence

机译：帕瓦仑基因启动子中的DNA甲基化增加与甲基苯丙胺依赖相关

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Aim: The parvalbumin (PV)-containing subgroup of GABAergic neurons is particularly affected in schizophrenia and animal models of psychosis, including after methamphetamine (METH) administration. We investigated whether METH dependence and METH-induced psychosis may involve an effect on DNA methylation of the PVALB promoter. Materials & methods: The methylation of a PVALB promoter sequence was determined in 100 METH-dependent and 102 control subjects using pyrosequencing. Results: A significant increase in PVALB methylation was observed in METH dependence and METH-induced psychosis. No significant effect on long interspersed nucleotide element-1 methylation, a measure of global DNA methylation, was observed. Conclusion: These results demonstrate a specific association between elevated PVALB methylation and METH-induced psychosis. This finding may contribute to the GABAergic deficits associated with METH dependence.

机译：目的：含有小白蛋白（PV）的GABA能神经元亚群在精神分裂症和精神病动物模型中尤其受影响，包括甲基苯丙胺（METH）给药后。我们研究了甲基苯丙胺依赖和甲基苯丙胺诱导的精神病是否可能影响PVALB启动子的DNA甲基化。材料与方法：采用焦磷酸测序法对100名甲基苯丙胺依赖性受试者和102名对照受试者的PVALB启动子序列进行甲基化检测。结果：甲基苯丙胺依赖和甲基苯丙胺诱导的精神病患者PVALB甲基化显著增加。未观察到对长时间散布的核苷酸元素-1甲基化（一种测量整体DNA甲基化的方法）有显著影响。结论：这些结果表明PVALB甲基化升高与甲基苯丙胺诱导的精神病之间存在特异性关联。这一发现可能有助于与冰毒依赖相关的GABA能缺陷。

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《Pharmacogenomics》 |2017年第14期|共6页
作者
Veerasakul Siriluk; Watiktinkorn Paritat; Thanoi Samur; Dalton Caroline F.; Fachim Helene A.; Nudmamud-Thanoi Sutisa; Reynolds Gavin P.;
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作者单位

Naresuan Univ Fac Med Sci Dept Anat Phitsanulok 65000 Thailand;

Synphaet Hosp Psychiat Dept Bangkok Thailand;

Naresuan Univ Fac Med Sci Dept Anat Phitsanulok 65000 Thailand;

Sheffield Hallam Univ Biomol Sci Res Ctr Sheffield S1 1WB S Yorkshire England;

Sheffield Hallam Univ Biomol Sci Res Ctr Sheffield S1 1WB S Yorkshire England;

Naresuan Univ Fac Med Sci Dept Anat Phitsanulok 65000 Thailand;

Naresuan Univ Ctr Excellence Med Biotechnol Fac Med Sci Phitsanulok 65000 Thailand;

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正文语种 eng
中图分类药学;
关键词
DNA methylation; methamphetamine dependence; parvalbumin;

机译：DNA甲基化;甲基苯丙胺依赖性;帕瓦尔美白;

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Increased DNA methylation in the parvalbumin gene promoter is associated with methamphetamine dependence

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