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Negative symptoms in schizophrenia: correlation with clinical and genetic factors

机译：精神分裂症中的阴性症状：与临床和遗传因素的相关性

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Aim: Explore the possible association between clinical factors and genetic variants of the dopamine pathways and negative symptoms. Materials & methods: Negative symptoms were assessed in 206 patients with schizophrenia using the Arabic version of the self-evaluation of negative symptoms scale and the Positive and Negative Syndrome Scale. Genotyping for COMT, DRD2, MTHFR and OPRM1 genes was performed. Results: Multivariable analysis showed that higher self-evaluation of negative symptoms scale scores were significantly associated with higher age, higher chlorpromazine-equivalent daily dose for typical antipsychotics and in married patients. Higher negative Positive and Negative Syndrome Scale scores were significantly associated with women and having the CT genotype for MTHFR c.677C>T (beta = 4.25; p = 0.008) compared with CC patients. Conclusion: Understanding both clinical/genetic factors could help improve the treatment of patients.
机译：目的：探讨多巴胺通路的临床因素和遗传变异与阴性症状之间的可能关联。材料与方法：采用阿拉伯语版的阴性症状自评量表和阳性与阴性综合征量表对206例精神分裂症患者进行阴性症状评估。对COMT、DRD2、MTHFR和OPRM1基因进行基因分型。结果：多变量分析显示，阴性症状自评量表得分越高，典型抗精神病药物和已婚患者的年龄越大，氯丙嗪当量日剂量越高。与CC患者相比，更高的阴性-阳性和阴性综合征评分与女性以及MTHFR c.677C>T（β=4.25；p=0.008）的CT基因型显著相关。结论：了解临床/遗传因素有助于改善患者的治疗。

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