Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and H-1-NMR Spectroscopy for Quality Assessment of DA-9801, A Standardised Dioscorea Extract

首页> 外文期刊>Phytochemical Analysis >Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and H-1-NMR Spectroscopy for Quality Assessment of DA-9801, A Standardised Dioscorea Extract

【24h】

Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and H-1-NMR Spectroscopy for Quality Assessment of DA-9801, A Standardised Dioscorea Extract

机译：UHPLC-QTOF / MS，HPLC-ELSD和H-1-NMR光谱对DA-9801质量评估的组合应用，标准化的Dioscorea提取物

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Introduction - DA-9801, a standardised 50% aqueous ethanolic extract of a mixture of Dioscorea japonica and D. nipponica, is a botanical drug candidate for the treatment of diabetic neuropathy, which finished its US phase II clinical trials recently. An advanced quality control method is needed for further development of DA-9801, considering its high contents of both primary and secondary metabolites. Objective - Development of a quality assessment strategy for DA-9801, based on the combination of UHPLC-QTOF/MS, HPLCELSD, and 1H-NMR spectroscopy.

机译：简介——DA-9801是一种标准化的50%水乙醇提取物，由薯蓣和穿龙薯蓣的混合物制成，是治疗糖尿病神经病变的候选植物药物，该药物最近完成了美国II期临床试验。考虑到DA-9801的初级和次级代谢产物含量都很高，需要一种先进的质量控制方法来进一步开发DA-9801。目标——基于UHPLC-QTOF/MS、HPLCELSD和1H-NMR波谱的组合，开发DA-9801的质量评估策略。

著录项

来源
《Phytochemical Analysis》 |2017年第3期|共10页
作者

展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类植物学;
关键词
DA-9801; quality assessment; UHPLC-QTOF; MS; HPLC-ELSD; H-1-NMR spectroscopy;

机译：DA-9801;质量评估;UHPLC-QTOF;MS;HPLC-ELSD;H-1-NMR光谱;

相似文献

外文文献
中文文献
专利

1. Survey of nutrients and quality assessment of crab paste by 1H NMR spectroscopy and multivariate data analysis [J] . YE YangFang, ZHANG LiMin, TANG HuiRu, 中国科学通报：英文版 . 2012,第025期
2. Neurotrophic activity of DA-9801, a mixture extract of Dioscorea japonica Thunb. and Dioscorea nipponica Makino, in vitro. [J] . Kim N, Kim SH, Kim YJ, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2011,第1期

机译：薯Di的混合物提取物DA-9801的神经营养活性。和Dioscorea nipponica Makino，在体外。
3. Screening of α-glucosidase inhibitors from green tea extracts using immobilized enzymes affinity capture combined with UHPLC-QTOF MS analysisf [J] . Shiren Deng, Linbo Xia, Hongbin Xiao Chemical Communications . 2014,第20期

机译：固定化酶亲和捕获结合UHPLC-QTOF MS分析从绿茶提取物中筛选α-葡萄糖苷酶抑制剂f
4. Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo [J] . Im-Sook Song, Tae Y Kong, Hyeon-Uk Jeong, BMC Complementary and Alternative Medicine . 2014,第1期

机译：评估人和大鼠体内DA-9801（一种用于糖尿病性神经病的标准化薯os提取物）的转运蛋白介导的草药-药物相互作用潜力
5. Identification of unknown metabolites in bamboo leaf extracts by a non-targeted metabolomics approach using UHPLC-QTOF MS/MS driven by chemometrics tools [C] . Gotz Schlotterbeck, Timm Hettich International Mass Spectrometry Conference . 2014

机译：用UHPLC-QTOF MS / MS由化学计量工具驱动的UHPLC-QTOF MS / MS鉴定竹叶提取物中未知代谢物
6. Applications of Py-GC-MS to the study of Maillard reaction: Mechanistic and food quality aspects. [D] . Wnorowski, Andrzej. 2004

机译：Py-GC-MS在美拉德反应研究中的应用：机理和食品质量方面。
7. Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801 a standardized dioscorea extract for diabetic neuropathy in human in vitro and rat in vivo [O] . Im-Sook Song, Tae Yeon Kong, Hyeon-Uk Jeong, 2014

机译：评估人和大鼠体内DA-9801（一种用于糖尿病性神经病的标准化薯os提取物）的转运蛋白介导的草药-药物相互作用潜力
8. Evaluation of the transporter-mediated herb-drug interaction potential of DA-9801, a standardized dioscorea extract for diabetic neuropathy, in human in vitro and rat in vivo [O] . Im-Sook Song, Tae Yeon Kong, Hyeon-Uk Jeong, 2014

机译：评估人和大鼠体内DA-9801（一种用于糖尿病性神经病的标准化薯os提取物）的转运蛋白介导的草药-药物相互作用潜力
9. Characterization Of The Hydrogenation Products Of Bix (Phenylethynyl) Benzene (DEB) Getter Using Combined GC/FTIR/MS, FT-Raman, and ATR Spectroscopies (U). Conference: ICAVs-6 Conference, Sonoma County, CA, June 9-12, 2011. [R] . G. L. Powell N. R. Smyrl 2011

机译：使用GC / FTIR / ms，FT-拉曼和aTR光谱联合（U）表征Bix（苯乙炔基）苯（DEB）吸气剂的加氢产物。会议：ICaVs-6会议，2011年6月9日至12日，加利福尼亚州索诺玛县。

Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and H-1-NMR Spectroscopy for Quality Assessment of DA-9801, A Standardised Dioscorea Extract

摘要

著录项

相似文献

相关主题

期刊订阅