Preparation, characterization and cytotoxic applications of curcumin-(+/-) alpha-lipoicacid coloaded phosphorylated chitosan nanoparticles in MDA MB231 breast cancer cell line

Gogoi Plabita; Dutta Anindita; Ramteke Anand; Maji Tarun Kumar

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Preparation, characterization and cytotoxic applications of curcumin-(+/-) alpha-lipoicacid coloaded phosphorylated chitosan nanoparticles in MDA MB231 breast cancer cell line

机译：MDA MB231乳腺癌细胞系中姜黄素 - （+/-）α-脂肪酸磷酸化脱氨酰纳米粒子的制备，表征和细胞毒性应用

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In the present work, curcumin in combination with (+/-) alpha-Lipoic acid were used as the active agents for the preparation of phosphorylated chitosan nanoparticle. Ionic gelation method was used for the successful fabrication of the nanoparticles. Effective incorporation of the drugs in the polymeric system was revealed by Fourier-transform infrared spectroscopy (FT-IR) and X-ray diffractometry (XRD). Scanning electron microscope, transmission electron microscope and dynamic light scattering method were used to analyze the morphology and dimensional characteristics of the nanoparticles. The swelling degree and drug release mechanism were studied at pH 5.0 and 7.4 for different time periods by UV-visible spectrophotometer. Cytotoxicity study was performed by MTT assay analysis on normal human lymphocyte and MDA MB 231 breast cancer cell line. Trypan blue dye exclusion assay was performed to confirm the anticancer effect of the nanoparticles. The properties of the prepared nanoparticles recommended their possible application as anticancer agents.

机译：在本研究中，姜黄素与（+/-）α-硫辛酸组合作为活性剂用于制备磷酸化壳聚糖纳米颗粒。采用离子凝胶法成功制备了纳米颗粒。通过傅立叶变换红外光谱（FT-IR）和X射线衍射（XRD）揭示了药物在聚合物体系中的有效掺入。利用扫描电子显微镜、透射电子显微镜和动态光散射法分析了纳米颗粒的形貌和尺寸特征。用紫外-可见分光光度计研究了在pH值为5.0和7.4的条件下，不同时间段的溶胀度和药物释放机制。MTT法检测正常人淋巴细胞和MDA MB 231乳腺癌细胞系的细胞毒性。台盼蓝染料排斥实验证实了纳米颗粒的抗癌作用。所制备的纳米颗粒的性质推荐了它们作为抗癌剂的可能应用。

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来源
《Polymers for advanced technologies》 |2020年第11期|共15页
作者
Gogoi Plabita; Dutta Anindita; Ramteke Anand; Maji Tarun Kumar;
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作者单位

Tezpur Univ Dept Chem Sci Tezpur 784028 Assam India;

Tezpur Univ Dept Mol Biol &

Biotechnol Tezpur Assam India;

Tezpur Univ Dept Mol Biol &

Biotechnol Tezpur Assam India;

Tezpur Univ Dept Chem Sci Tezpur 784028 Assam India;

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原文格式 PDF
正文语种 eng
中图分类高分子化合物工业（高聚物工业）;高分子化学（高聚物）;
关键词
(+/-) alpha-lipoic acid; curcumin; cytotoxicity; drug release; polymeric nanoparticles;

机译：（+/-）α-硫辛酸;姜黄素;细胞毒性;药物释放;聚合物纳米粒子;

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2. Preparations, Characterizations and Applications of Chitosan-based Nanoparticles [J] . 中国海洋大学学报（英文版） . 2007,第003期
3. Curcumin diethyl disuccinate encapsulated in chitosan/alginate nanoparticles for improvement of its in vitro cytotoxicity against MDA-MB-231 human breast cancer cells [J] . Bhunchu S., Muangnoi C., Rojsitthisak P. Die Pharmazie . 2016,第12期

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4. Enhanced preferential cytotoxicity through surface modification: synthesis, characterization and comparative in vitro evaluation of TritonX-100 modified and unmodified zinc oxide nanoparticles in human breast cancer cell (MDA-MB-231) [J] . Biplab KC, Siddhi Nath Paudel, Sagar Rayamajhi, Chemistry central journal . 2016,第1期

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5. Synthesis, Characterization, and Study of In Vitro Cytotoxicity of ZnO-Fe3O4 Magnetic Composite Nanoparticles in Human Breast Cancer Cell Line (MDA-MB-231) and Mouse Fibroblast (NIH 3T3) [J] . Gunjan Bisht, Sagar Rayamajhi, Biplab KC, Nanoscale Research Letters . 2016,第1期

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7. Citrate reduced gold nanoparticles conjugated with Boswellia sacra and Commiphora myrrha to cause cytotoxicity in breast cancer cells without harming health cells: "We three things of Orient are". [D] . Moses, Sherita L. 2016

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8. Synthesis Characterization and Study of In Vitro Cytotoxicity of ZnO-Fe3O4 Magnetic Composite Nanoparticles in Human Breast Cancer Cell Line (MDA-MB-231) and Mouse Fibroblast (NIH 3T3) [O] . Gunjan Bisht, Sagar Rayamajhi, Biplab KC, 2016

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9. Enhanced preferential cytotoxicity through surface modification: synthesis, characterization and comparative in vitro evaluation of TritonX-100 modified and unmodified zinc oxide nanoparticles in human breast cancer cell (MDA-MB-231) [O] . 2016

机译：通过表面修饰增强优先细胞毒性：TritonX-100修饰和未修饰的氧化锌纳米粒子在人乳腺癌细胞中的合成，表征和体外比较评估（MDA-MB-231）
10. Breaking Cancer Dormancy to Sensitize Dormant Breast Cancer Cells to Cytotoxic Chemotherapy. [R] . Tran, D. 2012

机译：打破癌症休眠，使休眠乳腺癌细胞对细胞毒性化疗敏感。

Preparation, characterization and cytotoxic applications of curcumin-(+/-) alpha-lipoicacid coloaded phosphorylated chitosan nanoparticles in MDA MB231 breast cancer cell line

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