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首页> 外文期刊>Poultry Science >Influence of mycotoxin binders on the oral bioavailability of tylosin, doxycycline, diclazuril, and salinomycin in fed broiler chickens
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Influence of mycotoxin binders on the oral bioavailability of tylosin, doxycycline, diclazuril, and salinomycin in fed broiler chickens

机译：霉菌毒素粘合剂对奶油鸡甲素，茂素，脱氯脲和盐霉素口腔生物利用度的影响

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摘要

The presence of mycotoxins in broiler feed can have deleterious effects on the wellbeing of the animals and their performance. Mycotoxin binders are feed additives that aim to adsorb mycotoxins in the intestinal tract and thereby prevent the oral absorption of the mycotoxin. The simultaneous administration of coccidiostats and/or antimicrobials with mycotoxin binders might lead to a reduced oral bioavailability of these veterinary medicinal products. This paper describes the influence of 3 mycotoxin binders (i.e., clay 1 containing montmorillonite, mica, and feldspars; clay 2 containing montmorillonite and quartz; and yeast 1 being a modified glucomannan fraction of inactivated yeast cells) and activated carbon on the oral bioavailability and pharmacokinetic parameters of the antimicrobials doxycycline and tylosin, and the coccidiostats diclazuril and salinomycin. A feeding study with 40 15 day-old broilers was performed evaluating the effects of long-term feeding 2 g mycotoxin binder/kg of feed. The birds were randomly divided into 5 groups of 8 birds each, i.e., a control group receiving no binder and 4 test groups receiving either clay 1, clay 2, yeast 1, or activated carbon mixed in the feed. After 15 d of feeding, both the control and each test group were administered doxycycline, tylosin, diclazuril, and salinomycin, consecutively, respecting a wash-out period of 2 to 3 d between each administration. The 4 medicinal products were dosed using a single bolus administration directly in the crop. After each bolus administration, blood was collected for plasma analysis and calculation of the main pharmacokinetic parameters and relative oral bioavailability (F = area under the plasma concentration-time curve (AUC(0-8) h) in the test groups/AUC(0-8) h in the control group)*100). No effects were observed of any of the mycotoxin binders on the relative oral bioavailability of the coccidiostats (i.e., F between 82 and 101% and 79 and 93% for diclazuril and salinomycin, respectively). Also, no significant effects could be noticed of any of the mycotoxin binders on the relative oral bioavailability of the antimicrobials doxycycline and tylosin (i.e., F between 67 and 83% and between 43 and 104%, respectively).
机译：肉鸡饲料中真菌毒素的存在会对动物的健康及其性能产生有害影响。真菌毒素粘合剂是一种饲料添加剂，旨在吸附肠道中的真菌毒素，从而防止真菌毒素的口服吸收。与真菌毒素粘合剂同时施用抗球虫药和/或抗菌剂可能会导致这些兽药产品的口服生物利用度降低。本文描述了3种真菌毒素粘合剂（即粘土1含有蒙脱石、云母和长石；粘土2含有蒙脱石和石英；酵母1是灭活酵母细胞的改性葡甘聚糖部分）和活性炭对抗菌剂强力霉素和泰乐菌素的口服生物利用度和药代动力学参数的影响，还有抗球虫药地克珠利和盐霉素。对40只15日龄肉鸡进行了饲养研究，评估了每千克饲料长期饲喂2克真菌毒素粘合剂的效果。将这些鸟随机分为5组，每组8只，即不使用粘合剂的对照组和使用粘土1、粘土2、酵母1或混合在饲料中的活性炭的4个试验组。喂食15天后，对照组和每个试验组连续服用强力霉素、泰乐菌素、地克珠利和盐霉素，每次给药之间的清洗期为2至3天。这4种药物直接在作物中单次给药。每次给药后，采集血液进行血浆分析，并计算主要药代动力学参数和相对口服生物利用度（F=血浆浓度-时间曲线下的面积（试验组的AUC（0-8）h/对照组的AUC（0-8）h）*100）。未观察到任何真菌毒素粘合剂对球虫抑制剂的相对口服生物利用度的影响（即，地克珠利和盐霉素的F分别在82%和101%之间，79%和93%之间）。此外，未发现任何真菌毒素粘合剂对抗菌剂强力霉素和泰乐菌素的相对口服生物利用度有显著影响（即F分别在67%和83%之间以及43%和104%之间）。

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