Rapid systemic uptake of naloxone after intranasal administration in children

Olsson Eva Malmros; Lonnqvist Per-Arne; Stiller Carl-Olav; Eksborg Staffan; Lundeberg Stefan

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Rapid systemic uptake of naloxone after intranasal administration in children

机译：鼻内给予儿童鼻内给药后的快速全身吸收纳洛酮

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Background Naloxone has a high affinity for the mu-opioid receptor and acts as a competitive antagonist, thus reversing the effects of opioids. Naloxone is often administrated intravenously, but there is a growing interest in the intranasal route in treating patients with opioid overdose, and in reversing effects after therapeutic use of opioids. As administration is painless and no intravenous access is needed, the intranasal route is especially useful in children.

机译：背景纳洛酮对mu阿片受体具有高度亲和力，并作为竞争性拮抗剂，从而逆转阿片类药物的作用。纳洛酮通常是静脉给药，但人们越来越感兴趣的是鼻腔给药途径治疗阿片类药物过量患者，以及逆转阿片类药物治疗后的效果。由于给药无痛且无需静脉注射，鼻内途径对儿童尤其有用。

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来源
《Paediatric anaesthesia》 |2021年第6期|共6页
作者
Olsson Eva Malmros; Lonnqvist Per-Arne; Stiller Carl-Olav; Eksborg Staffan; Lundeberg Stefan;
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作者单位

Karolinska Univ Hosp Astrid Lindgren Childrens Hosp Pediat Pain Treatment Serv Stockholm Sweden;

Karolinska Univ Hosp Pediat Perioperat Med &

Intens Care Stockholm Sweden;

Karolinska Inst Dept Med Clin Pharmacol Unit Stockholm Sweden;

Karolinska Univ Hosp Pediat Perioperat Med &

Intens Care Stockholm Sweden;

Karolinska Univ Hosp Astrid Lindgren Childrens Hosp Pediat Pain Treatment Serv Stockholm Sweden;

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原文格式 PDF
正文语种 eng
中图分类麻醉学;
关键词
children; intranasal; naloxone; pediatric; pharmacokinetic; uptake;

机译：儿童;鼻内;纳洛酮;小儿科;药代动力学;摄取;

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Rapid systemic uptake of naloxone after intranasal administration in children

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