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首页> 外文期刊>Plasma Sources Science & Technology >Reactions of nitroxide radicals in aqueous solutions exposed to non-thermal plasma: limitations of spin trapping of the plasma induced species
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Reactions of nitroxide radicals in aqueous solutions exposed to non-thermal plasma: limitations of spin trapping of the plasma induced species

机译：氮氧化物基团在暴露于非热等离子体的水溶液中的反应：血浆诱导物种的旋转捕获的限制

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摘要

Low temperature ('cold') atmospheric pressure plasmas have gained much attention in recent years due to their biomedical effects achieved through the interactions of plasma-induced species with the biological substrate. Monitoring of the radical species in an aqueous biological milieu is usually performed via electron paramagnetic resonance (EPR) spectroscopy using various nitrone spin traps, which form persistent radical adducts with the short-lived radicals. However, the stability of these nitroxide radical adducts in the plasma-specific environment is not well known. In this work, chemical transformations of nitroxide radicals in aqueous solutions using a model nitroxide 4-oxo-TEMPO were studied using EPR and LC-MS. The kinetics of the nitroxide decay when the solution was exposed to plasma were assessed, and the reactive pathways proposed. The use of different scavengers enabled identification of the types of reactive species which cause the decay, indicating the predominant nitroxide group reduction in oxygen-free plasmas. The H-2 adduct of the PBN spin trap (PBN-D) was shown to decay similarly to the model molecule 4-oxo-TEMPO. The decay of the spin adducts in plasma-treated solutions must be considered to avoid rendering the spin trapping results unreliable. In particular, the selectivity of the decay indicated the limitations of the PTIO/PTI nitroxide system in the detection of nitric oxide.
机译：低温（冷）大气压等离子体由于其通过等离子体诱导物种与生物基质的相互作用而实现的生物医学效应，近年来受到了广泛关注。在水相生物环境中，自由基物种的监测通常通过电子顺磁共振（EPR）光谱进行，使用各种硝基自旋陷阱，这些陷阱与短寿命自由基形成持久的自由基加合物。然而，这些氮氧自由基加合物在血浆特定环境中的稳定性尚不清楚。在这项工作中，使用EPR和LC-MS研究了水溶液中氮氧化物自由基在模型氮氧化物4-氧代-TEMPO中的化学转化。评估了溶液暴露于等离子体时氮氧化物衰变的动力学，并提出了反应途径。使用不同的清除剂能够识别导致衰变的活性物种的类型，表明无氧等离子体中主要的氮氧基团减少。PBN自旋阱（PBN-D）的H-2加合物的衰变与模型分子4-氧代-天冬氨酸类似。必须考虑等离子体处理溶液中自旋加合物的衰变，以避免使自旋捕获结果不可靠。特别是，衰变的选择性表明了PTIO/PTI氮氧化物系统在检测一氧化氮方面的局限性。

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