Decreased turnover aspirin resistance by bidaily aspirin intake and efficient cytoreduction in myeloproliferative neoplasms

Perrier-Cornet Andreas; Ianotto Jean-Christophe; Mingant Fanny; Perrot Maela; Lippert Eric; Galinat Hubert

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Decreased turnover aspirin resistance by bidaily aspirin intake and efficient cytoreduction in myeloproliferative neoplasms

机译：通过Bidaily Aspirin进气和高效细胞渗透培养的胞质瘤瘤中的营养素抵抗力减少

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Essential thrombocythemia (ET) and polycythemia vera (PV) are myeloproliferative neoplasms (MPN) with an increased risk of arterial and venous thrombosis. Aspirin is recommended to reduce this risk, but resistance to antiplatelet therapy seems to hamper its efficacy in some patients. We have previously shown that multiple electrode aggregometry (MEA) was a valuable tool to assess aspirin resistance in MPN. In this study, MEA was used to assess the reduction in aspirin resistance after bi-daily (BID) aspirin intake or cytoreduction.

机译：原发性血小板增多症（ET）和真性红细胞增多症（PV）是骨髓增生性肿瘤（MPN），动脉和静脉血栓形成的风险增加。建议使用阿司匹林来降低这种风险，但抗血小板治疗的耐药性似乎会阻碍其在某些患者中的疗效。我们之前已经证明，多电极聚集测定法（MEA）是评估MPN患者阿司匹林抵抗的一种有价值的工具。在这项研究中，MEA用于评估每日两次（BID）服用阿司匹林或细胞减少后阿司匹林抵抗的降低。

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来源
《Platelets》 |2018年第7期|共6页
作者
Perrier-Cornet Andreas; Ianotto Jean-Christophe; Mingant Fanny; Perrot Maela; Lippert Eric; Galinat Hubert;
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作者单位

CHU Brest Serv Hematol Biol Blvd Tanguy Prigent F-29609 Brest France;

CHU Brest Serv Hematol Clin Brest France;

CHU Brest Serv Hematol Biol Blvd Tanguy Prigent F-29609 Brest France;

CHU Brest Serv Hematol Biol Blvd Tanguy Prigent F-29609 Brest France;

CHU Brest Serv Hematol Biol Blvd Tanguy Prigent F-29609 Brest France;

CHU Brest Serv Hematol Biol Blvd Tanguy Prigent F-29609 Brest France;

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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Aspirin resistance; multiple electrode aggregometry; myeloproliferative neoplasm; platelet turnover;

机译：阿司匹林抵抗;多电极聚集体;肌酚植物肿瘤;血小板周转;

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专利

1. Earlier application of loading doses of aspirin and clopidogrel decreases rate of recurrent cardiovascular ischemic events for patients undergoing percutaneous coronary intervention [J] . TANG Fa-kuan, LIN Le-jian, HUA Ning, 中华医学杂志（英文版） . 2012,第004期
2. The incidence of aspirin resistance and relevant influencing factors in patients on maintenance hemodialysis [J] . 张春华中国医学文摘：内科学分册（英文版） . 2014,第002期
3. Decreased turnover aspirin resistance by bidaily aspirin intake and efficient cytoreduction in myeloproliferative neoplasms [J] . Perrier-Cornet Andreas, Ianotto Jean-Christophe, Mingant Fanny, Platelets . 2018,第7期

机译：通过Bidaily Aspirin进气和高效细胞渗透培养的胞质瘤瘤中的营养素抵抗力减少
4. Multiple Electrode Aggregometry is an adequate method for aspirin response testing in myeloproliferative neoplasms and differentiates the mechanisms of aspirin resistance [J] . Gillet Benjamin, Ianotto Jean-Christophe, Mingant Fanny, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016,第Null期

机译：多电极凝集测定法是一种用于检测骨髓增生性肿瘤中阿司匹林反应的适当方法，可区分阿司匹林抵抗的机制
5. Multiple Electrode Aggregometry is an adequate method for aspirin response testing in myeloproliferative neoplasms and differentiates the mechanisms of aspirin resistance [J] . Gillet Benjamin, Ianotto Jean-Christophe, Mingant Fanny, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016,第Null期

机译：多电极聚集体是一种足够的Aspirin响应试验在髓原肿瘤中进行的方法，并区分阿司匹林抗性机制
6. ASPIRIN RESISTANCE: WHAT DO WE REALLY KNOW? [C] . John M. Thomason Conference of the American College of Veterinary Internal Medicine . 2013

机译：阿司匹林抵抗：我们真正知道什么？
7. Transcriptional and Proteomic Changes Associated with the Sensitivity and Resistance to JAK2 Inhibitors: Implications for the Treatment of BCR-ABL (-) Myeloproliferative Neoplasms (MPNs). [D] . McDevitt, Theresa Marie. 2012

机译：与JAK2抑制剂的敏感性和抗性相关的转录和蛋白质组学变化：对BCR-ABL（-）骨髓增生性肿瘤（MPNs）的治疗意义。
8. Investigating the effectiveness of different aspirin dosing regimens and the timing of aspirin intake in primary and secondary prevention of cardiovascular disease: protocol for a systematic review [O] . Danai Bem, Janine Dretzke, Simon Stevens, 2015

机译：研究不同的阿司匹林给药方案的有效性和阿司匹林摄入量在心血管疾病的一级和二级预防中的作用：系统评价方案
9. Unexpected low expression of platelet fibrinogen receptor in patients with chronic myeloproliferative neoplasms: how does it change with aspirin? [O] . Alessandro Lucchesi, Silvia Carloni, Serena De Matteis, 2019

机译：慢性髓原肿瘤患者血小板纤维蛋白原受体的意外低表达：它是如何用阿司匹林改变的？

Decreased turnover aspirin resistance by bidaily aspirin intake and efficient cytoreduction in myeloproliferative neoplasms

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