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Platelet concentrates for bone regeneration: Current evidence and future challenges

机译：血小板浓缩物用于骨再生：当前的证据和未来的挑战

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Activated platelet concentrates are autologous blood preparations containing supraphysiological concentration of platelets. Platelet concentrates are commonly used for bone regeneration purposes based on the fact that growth factors released from activated platelets alpha granules have osteoinductive effects on bone cells. Although most preclinical and clinical studies show that platelet concentrates improve the outcomes of bone regeneration procedures, some studies reported conflicting results and even negative effects on bone healing. Several confounding parameters have been suggested as possible reasons for such inconsistencies (i.e. preparation and activation methods). However, heterogeneity in clinical studies makes drawing evidence-based conclusions difficult. On the other hand, recent findings show that the constituents of platelets dense granules (i.e. serotonin, ATP, Ca2+) have potential inhibitory effects on bone metabolism. Accordingly, we suggest that a partial explanation for the conflicting results could be the potential negative effects that dense granules may have on bone healing.
机译：活化血小板浓缩物是含有超生理浓度血小板的自体血液制剂。血小板浓缩物通常用于骨再生目的，因为活化血小板α颗粒释放的生长因子对骨细胞具有骨诱导作用。尽管大多数临床前和临床研究表明，血小板浓缩物可以改善骨再生过程的结果，但一些研究报告了相互矛盾的结果，甚至对骨愈合有负面影响。有人提出了几个混杂参数作为此类不一致的可能原因（即制备和激活方法）。然而，临床研究中的异质性使得难以得出基于证据的结论。另一方面，最近的研究结果表明，血小板致密颗粒的成分（即5-羟色胺、ATP、Ca2+）对骨代谢有潜在的抑制作用。因此，我们认为，对相互矛盾的结果的部分解释可能是致密颗粒可能对骨愈合产生的潜在负面影响。

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