• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Platelets >Platelet count and risk of major bleeding in venous thromboembolism
【24h】

Platelet count and risk of major bleeding in venous thromboembolism

机译：静脉血栓栓塞中重大出血的血小板计数与风险

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The relationship between platelet count and risk of major bleeding in patients with venous thromboembolism (VTE) during anticoagulation remains unclear. We therefore investigated the association between platelet count, measured at VTE diagnosis and before the thrombotic event, and risk of major bleeding. Participants comprised 744 patients with incident VTE derived from the Tromso Study. Major bleedings were recorded during the first year after VTE. Cox-regression was used to calculate hazard ratios (HRs) for major bleeding across platelet count quartiles. There were 55 major bleedings (incidence rate 9.1/100 person-years, 95% confidence interval [CI] 7.0-11.8). The major bleeding risk increased across quartiles of platelet count measured at VTE diagnosis (Pfor trend = 300x10(9)/L) had a 4.3-fold (95% CI 1.7-10.9) higher risk of major bleeding compared to those with platelet count in the lowest quartile (<= 192x10(9)/L), and exclusion of patients with cancer yielded similar results. When platelet count was measured on average 7 years before a VTE, the corresponding HR was 2.5 (95% CI 0.9-6.7). Our results suggest that increasing platelet count, assessed several years before and at VTE diagnosis, is associated with a higher risk of major bleeding, and could be a stable individual marker of major bleeding risk in VTE-patients.
机译：静脉血栓栓塞症（VTE）患者抗凝期间血小板计数与大出血风险之间的关系尚不清楚。因此，我们研究了VTE诊断时和血栓事件发生前测得的血小板计数与大出血风险之间的关系。参与者包括744名来自Tromso研究的意外VTE患者。在VTE后的第一年记录了大出血。Cox回归用于计算血小板计数四分位数中大出血的危险比（HRs）。共有55例大出血（发病率9.1/100人年，95%可信区间[CI]7.0-11.8）。在VTE诊断时（Pfor趋势=300x10（9）/L）测量的血小板计数的四分位数中，大出血风险增加，与血小板计数在最低四分位数（<=192x10（9）/L）的患者相比，大出血风险高4.3倍（95%可信区间1.7-10.9），排除癌症患者也产生了类似的结果。在VTE前7年平均测量血小板计数时，相应的HR为2.5（95%可信区间为0.9-6.7）。我们的结果表明，在VTE诊断前几年和诊断时评估的血小板计数增加与严重出血的风险较高相关，并且可能是VTE患者严重出血风险的一个稳定个体标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号