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首页> 外文期刊>Platelets >The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function
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The use of regression analysis in determining reference intervals for low hematocrit and thrombocyte count in multiple electrode aggregometry and platelet function analyzer 100 testing of platelet function

机译：使用回归分析在多电极聚合物和血小板函数分析仪100中测定低血细胞比容和血小板减少的参考间隔，血小板函数的测试

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摘要

Low platelet counts and hematocrit levels hinder whole blood point-of-care testing of platelet function. Thus far, no reference ranges for MEA (multiple electrode aggregometry) and PFA-100 (platelet function analyzer 100) devices exist for low ranges. Through dilution methods of volunteer whole blood, platelet function at low ranges of platelet count and hematocrit levels was assessed on MEA for four agonists and for PFA-100 in two cartridges. Using (multiple) regression analysis, 95% reference intervals were computed for these low ranges. Low platelet counts affected MEA in a positive correlation (all agonists showed r(2) >= 0.75) and PFA-100 in an inverse correlation (closure times were prolonged with lower platelet counts). Lowered hematocrit did not affect MEA testing, except for arachidonic acid activation (ASPI), which showed a weak positive correlation (r(2) = 0.14). Closure time on PFA-100 testing was inversely correlated with hematocrit for both cartridges. Regression analysis revealed different 95% reference intervals in comparison with originally established intervals for both MEA and PFA-100 in low platelet or hematocrit conditions. Multiple regression analysis of ASPI and both tests on the PFA-100 for combined low platelet and hematocrit conditions revealed that only PFA-100 testing should be adjusted for both thrombocytopenia and anemia. 95% reference intervals were calculated using multiple regression analysis. However, coefficients of determination of PFA-100 were poor, and some variance remained unexplained. Thus, in this pilot study using (multiple) regression analysis, we could establish reference intervals of platelet function in anemia and thrombocytopenia conditions on PFA-100 and in thrombocytopenia conditions on MEA.
机译：低血小板计数和红细胞压积水平阻碍全血护理点血小板功能检测。到目前为止，MEA（多电极聚集仪）和PFA-100（血小板功能分析仪100）设备的低范围参考范围尚不存在。通过对志愿者全血的稀释方法，在低范围的血小板计数和红细胞压积水平下，对四种激动剂和两盒PFA-100的MEA进行血小板功能评估。使用（多元）回归分析，针对这些低范围计算了95%的参考区间。低血小板计数与MEA呈正相关（所有激动剂均显示r（2）>=0.75），而PFA-100呈负相关（血小板计数越低，关闭时间越长）。红细胞压积降低不影响MEA检测，但花生四烯酸激活（ASPI）除外，后者呈弱正相关（r（2）=0.14）。PFA-100检测的闭合时间与两种药筒的红细胞压积呈负相关。回归分析显示，在血小板或红细胞压积较低的情况下，MEA和PFA-100的95%参考区间与最初确定的区间不同。ASPI的多元回归分析和PFA-100对血小板和红细胞压积联合检测结果显示，血小板减少和贫血只需调整PFA-100检测。使用多元回归分析计算95%的参考区间。然而，PFA-100的测定系数很差，一些差异仍然无法解释。因此，在这项使用（多元）回归分析的初步研究中，我们可以通过PFA-100和MEA建立贫血和血小板减少症患者血小板功能的参考区间。

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