• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Platelets >Platelet count and function in umbilical cord blood versus peripheral blood in term neonates
【24h】

Platelet count and function in umbilical cord blood versus peripheral blood in term neonates

机译：脐带血血小板计数和功能在新生儿中的外周血

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Platelet function in neonates is sparsely investigated. The majority of previous studies investigated platelets in umbilical cord (UC) blood rather than in peripheral blood. We included 20 term neonates and sampled UC blood and peripheral blood within 20 min and 24 h after birth. Platelet count and mean platelet volume (MPV) were measured. Platelet surface glycoproteins (GP) and platelet activation (bound fibrinogen, CD63 andp-selectin) after agonist stimulation were examined by flow cytometry. Platelet aggregation was evaluated by impedance aggregometry. The significance level was set after Bonferroni correction. Platelet count and MPV did not differ between UC and peripheral blood (p-values >0.08). Expression of platelet surface GP was similar in UC and peripheral blood (allp-values >0.02). Platelet activation was lower in UC blood than in peripheral blood for bound fibrinogen (four out of eightp-values 0.01) orP-selectin (allp-values >0.01). Platelet aggregation was significantly higher in UC than in peripheral blood (p-values <0.001). In conclusion, platelet count, MPV and expression of platelet surface GP measured in term neonatal UC blood represented that of peripheral blood. Platelet activation and aggregation in UC blood did not reflect that of peripheral blood.
机译：新生儿血小板功能的研究很少。以前的大多数研究调查的是脐带血（UC）中的血小板，而不是外周血中的血小板。我们包括20名足月新生儿，并在出生后20分钟和24小时内采集UC血液和外周血。测定血小板计数和平均血小板体积（MPV）。流式细胞术检测激动剂刺激后血小板表面糖蛋白（GP）和血小板活化（结合纤维蛋白原、CD63和P选择素）。通过阻抗聚集仪评估血小板聚集。显著性水平在Bonferroni校正后设定。UC和外周血之间的血小板计数和MPV没有差异（p值>0.08）。UC和外周血中血小板表面糖蛋白的表达相似（allp值>0.02）。UC血液中结合纤维蛋白原（八分之四的TP值为0.01）或选择素（allp值>0.01）的血小板活化率低于外周血。UC患者的血小板聚集率显著高于外周血（p值<0.001）。综上所述，足月新生儿UC血液中测得的血小板计数、MPV和血小板表面糖蛋白的表达代表了外周血。UC血液中的血小板活化和聚集不能反映外周血中的血小板活化和聚集。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号