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Platelets and Extracellular Traps in Infections

机译：血小板和细胞外陷阱在感染中

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Platelets have a well-recognized role in hemostasis and thrombosis, and they are important amplifiers of inflammation and innate immune responses. The formation of DNA extracellular traps (ETs) is a complex cellular mechanism, which occurs in response to microbial infections and sterile inflammation, and results in the release of DNA complexed with histones and various granular proteins. ETs were first discovered in neutrophils (NETs); however, it is now accepted that other leukocytes, including eosinophils (EETs) and monocytes/macrophages (MoETs/METs), can also generate them. Moreover, several types of ETs have been described. Increasing evidence has demonstrated that platelets modulate the formation of ETs. This review summarizes recent findings about the physiopathological role of platelets in the formation of ETs during infection and future perspectives in the field.
机译：血小板在止血和血栓形成中具有公认的作用，它们是炎症和先天免疫反应的重要放大器。DNA胞外陷阱（ETs）的形成是一种复杂的细胞机制，它发生在微生物感染和无菌炎症反应中，导致与组蛋白和各种颗粒蛋白复合的DNA释放。ETs首先在中性粒细胞（NETs）中发现；然而，现在人们普遍认为，包括嗜酸性粒细胞（EET）和单核细胞/巨噬细胞（MOET/MET）在内的其他白细胞也能产生它们。此外，还描述了几种类型的ETs。越来越多的证据表明血小板调节内皮祖细胞的形成。本文综述了近年来有关血小板在感染期间ETs形成中的生理病理作用的研究结果，以及该领域的未来展望。

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