• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Platelets >Investigation of fibrinogen in early bleeding of patients with newly diagnosed acute promyelocytic leukemia
【24h】

Investigation of fibrinogen in early bleeding of patients with newly diagnosed acute promyelocytic leukemia

机译：新诊断急性突出细胞白血病患者早期出血中纤维蛋白原的研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Early hemorrhagic death remains a major cause of treatment failure in acute promyelocytic leukemia (APL). This study investigated the role of fibrinogen concentrations in early hemorrhage and overall survival (OS) of APL patients. Laboratory and clinical data, including fibrinogen concentrations and other coagulation indexes, bleeding events, and survival data, of 198 patients newly diagnosed with APL from February 2012 to December 2017 were extracted from patient records and retrospectively investigated. Patients with moderate/severe bleeding had significantly lower median fibrinogen concentrations (p= .023), higher Chinese disseminated intravascular coagulation scoring system (CDSS) (p = 5 (p= .023) were independent risk factors for moderate/severe bleeding. Survival analysis indicated that moderate/severe bleeding (p= .018), fibrinogen 12.8 s (p= .005), age >= 60 years (p= .001), and CDSS >= 5 (p= .044) were independent predictors of 1-year OS. Fibrinogen 1.6 g/L may help to prevent bleeding.
机译：早期出血性死亡仍然是急性早幼粒细胞白血病（APL）治疗失败的主要原因。本研究调查了纤维蛋白原浓度在APL患者早期出血和总生存率（OS）中的作用。从患者记录中提取2012年2月至2017年12月期间198例新诊断为APL患者的实验室和临床数据，包括纤维蛋白原浓度和其他凝血指标、出血事件和生存数据，并进行回顾性调查。中/重度出血患者的纤维蛋白原中位浓度显著降低（p=0.023），中国弥散性血管内凝血评分系统（CDSS）较高（p=5（p=0.023）是中/重度出血的独立危险因素。生存分析表明，中度/重度出血（p=0.018）、纤维蛋白原12.8s（p=0.005）、年龄>=60岁（p=0.001）和CDSS>=5（p=0.044）是1年OS的独立预测因子。纤维蛋白原1.6 g/L可能有助于防止出血。

著录项

  • 来源
    《Platelets》 |2021年第5期|共7页
  • 作者

    Chu Tiantian; Wang Hong; Lv Xin; Qi Jiaqian; Tang Yaqiong; Fan Yi; Qiu Huiying; Tang Xiaowen; Fu Chengcheng; Ruan Changgeng; Han Yue; Wu De-Pei;

  • 作者单位

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

    Soochow Univ Jiangsu Inst Hematol Affiliated Hosp 1 88 Shizi St Suzhou 215000 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 基础医学;
  • 关键词

    Acute promyelocytic leukemia; bleeding; fibrinogen; overall survival;

    机译：急性早野细胞白血病;出血;纤维蛋白原;总体生存;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号