A third factor Xa inhibitor anticoagulant: no proven advantages

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A third factor Xa inhibitor anticoagulant: no proven advantages

机译：第三个因素XA抑制剂抗凝血剂：没有经过验证的优势

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Adjusted-dose warfarin is the standard treatment for prevention of throm-boembolic events in high-risk patients with atrial fibrillation (2).An oral anticoagulant such as dabi-gatran, a thrombin inhibitor, is an alternative to warfarin when vitamin K antagonists fail to maintain the international normalised ratio (INR) within the therapeutic range.Edoxaban (Lixiana0, Daiichi Sankyo), a factor Xa inhibitor, has been author-. ised in the EU for use in these clinical situations. Does it represent an advance over existing options?

机译：调整剂量华法林是预防房颤高危患者血栓栓塞事件的标准治疗方法（2）。当维生素K拮抗剂无法将国际标准化比值（INR）维持在治疗范围内时，口服抗凝剂（如凝血酶抑制剂达比加群）是华法林的替代品。Xa因子抑制剂Edoxaban（Lixiana0，Daiichi Sankyo）是作者-。在欧盟使用，用于这些临床情况。它是否代表了对现有选项的进步？

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《Prescrire international》 |2017年第178期|共1页
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正文语种 eng
中图分类药学;
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1. Rate of anticoagulant use, and factors associated with not prescribing anticoagulant in older Thai adults with non-valvular atrial fibrillation:A multicenter registry [J] . Rungroj Krittayaphong, Arintaya Phrommintikul, Pornchai Ngamjanyaporn, 老年心脏病学杂志（英文版） . 2019,第003期
2. Dauricine inhibits insulin-like growth factor-Ⅰ-induced hypoxia inducible factor 1α protein accumulation and vascular endothelial growth factor expression in human breast cancer cells [J] . Xu-dong TANG, Xin ZHOU, Ke-yuan ZHOU 中国药理学报：英文版 . 2009,第005期
3. Factors influencing adherence to non-vitamin K antagonist oral anticoagulants in the early period after atrial fibrillation catheter ablation in China [J] . Zhi-Cheng Hu, Shang-Yu Liu, Ling-Min Wu, 中华医学杂志（英文版） . 2020,第016期
4. Fibrin-targeted direct factor Xa inhibition: construction and characterization of a recombinant factor Xa inhibitor composed of an anti-fibrin single-chain antibody and tick anticoagulant peptide. [J] . Hagemeyer CE, Tomic I, Jaminet P, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2004,第1期

机译：靶向血纤蛋白的直接因子Xa抑制：由抗血纤蛋白单链抗体和壁虱抗凝血肽组成的重组因子Xa抑制剂的构建和表征。
5. Effects of the oral, direct factor Xa inhibitor edoxaban on routine coagulation assays, lupus anticoagulant and anti-Xa assays [J] . Hillarp Andreas, Strandberg Karin, Baghaei Fariba, Scandinavian journal of clinical and laboratory investigation. . 2018,第8期

机译：口服，直接因子XA抑制剂Edoxaban对常规凝血测定，狼疮抗凝血和抗XA测定的影响
6. Effects of the oral, direct factor Xa inhibitor edoxaban on routine coagulation assays, lupus anticoagulant and anti-Xa assays [J] . Hillarp Andreas, Strandberg Karin, Baghaei Fariba, Scandinavian journal of clinical and laboratory investigation. . 2018,第7期

机译：口服，直接因子XA抑制剂Edoxaban对常规凝血测定，狼疮抗凝血和抗XA测定的影响
7. Assessment of the efficacy of tissue factor pathway inhibitor (TFPI) immobilized on glass slides to inhibit factor Xa under flow conditions [C] . Chandiwal, A., Mast, . 2002

机译：评估流动条件下固定在载玻片上的组织因子途径抑制剂（TFPI）抑制Xa因子的功效
8. A new mechanism-driven bypassing strategy for direct factor Xa inhibitors reveals an unexpected property of target specific anticoagulants. [D] . Thalji, Nabil K. 2015

机译：直接因子Xa抑制剂的新机制驱动旁路策略揭示了靶标特异性抗凝剂的出乎意料的特性。
9. Synthesis Docking and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo321-ijQuinolin-2(1H)-one as New Inhibitors of Factor Xa and Factor XIa [O] . Nadezhda Novichikhina, Ivan Ilin, Anna Tashchilova, 2020

机译：Pyrrolo 321-ij Quinolin-2（1H）-作为因子Xa和XIa新抑制剂的杂合物的合成对接和体外抗凝血活性测定
10. Evaluation of a New Blood Coagulation Factor Xa Inhibitor, KFA-1411, as an Anticoagulant in a Cynomolgus Monkey Hemodialysis Model: Parameters Suitable for Monitoring Anticoagulant Activities [O] . Kiyoto Hara, Toshiki Honma, Yuji Hoyano, 2003

机译：评价新的血液凝固因子XA抑制剂，KFA-1411，作为一种抗凝血剂在Cynomolgus血液透析模型中：适用于监测抗凝血活动的参数
11. Effect of Anticoagulants and Heat on the Detection of Tumor Necrosis Factor inMurine Blood [R] . Holobaugh, P. A., McChesney, D. C. 1990

机译：抗凝剂和热剂对血液中肿瘤坏死因子检测的影响

A third factor Xa inhibitor anticoagulant: no proven advantages

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