Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia

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Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia

机译：甲基氯普胺，DOMPERIDONE：突然的心脏死亡，心间心律失常

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The results of two large epidemio-logical studies on the association between domperidone and ventricular arrhythmia or sudden cardiac death were published in 2015; one study was conducted in Taiwan and the other in the United Kingdom. They also examined metoclopramide. Both studies demonstrated an increased risk of sudden cardiac death and ventricular arrhythmia with metoclopramide, similar to the risk associated with domperidone. The results concerning domperidone were consistent with those of previous studies. In particular, they showed that the risk was higher with doses greater than 30 mg per day or with concomitant use of inhibitors of the cytochrome P450 isoenzyme CYP3A4, which reduce domperidone clearance. In practice, metoclopramide has a marginal role in patient care, with minor efficacy. Domperidone should not be used at all; its efficacy at the approved dose, beyond a placebo effect, is uncertain.

机译：2015年发表了两项关于多潘立酮与室性心律失常或心源性猝死之间关系的大型流行病学研究结果；一项研究在台湾进行，另一项在英国进行。他们还检查了甲氧氯普胺。两项研究均表明，甲氧氯普胺增加了心源性猝死和室性心律失常的风险，与多潘立酮的风险相似。多潘立酮的结果与之前的研究结果一致。特别是，他们表明，每天剂量超过30毫克或同时使用细胞色素P450同功酶CYP3A4抑制剂（可降低多潘立酮清除率）的风险更高。在实践中，甲氧氯普胺在患者护理中的作用微乎其微，疗效甚微。多潘立酮完全不应该使用；除了安慰剂效应外，其在批准剂量下的疗效尚不确定。

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《Prescrire international》 |2016年第175期|共3页
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1. Prognostic factors affecting the all-cause death and sudden cardiac death rates of post myocardial infarction patients with low left ventricular ejection fraction [J] . DAI Shi-mo, ZHANG Shu, CHEN Ke-ping, 中华医学杂志（英文版） . 2009,第007期
2. Heart rate-adjusted PR as a prognostic marker of long-term ventricular arrhythmias and cardiac death in ICD/CRT-D recipients [J] . Yu-Qiu LI, Xiao-Han FAN, Shu ZHANG, 老年心脏病学杂志（英文版） . 2019,第003期
3. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC) [J] . Priori Silvia G., Blomstrom-Lundqvist Carina, Mazzanti Andrea, European Heart Journal: The Journal of the European Society of Cardiology . 2015,第41期

机译：欧洲心脏病学会（ESC）2015年ESC室性心律失常患者治疗指南和预防心源性猝死欧洲心脏协会（ESC）室性心律失常患者治疗和预防心源性猝死预防特别工作组认可：欧洲小儿和先天性心脏病（AEPC）
4. Domperidone (Motilium) - serious ventricular arrhythmias and sudden cardiac death [J] . Australian prescriber . 2012,第6期

机译：DOMPERIDONE（Motilium） - 严重的心间心律失常和突然的心脏死亡
5. Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control study. [J] . Johannes CB, Varas Lorenzo C, McQuay LJ, Pharmacoepidemiology and drug safety . 2010,第9期

机译：一组使用多潘立酮的人发生严重心律失常和心源性猝死的风险：一项嵌套的病例对照研究。
6. Telemedicine application for predicting ventricular arrhythmia and sudden cardiac death by the analysis of phase synchronization in heart failure patients [C] . Khoor S, Szuszai T, Balogh N, Computing in Cardiology 2012.;vol. 39. . 2012

机译：心力衰竭患者的相位同步分析在远程医疗中预测室性心律失常和心源性猝死
7. Functional characterization of SCN5A, the cardiac sodium channel gene associated with cardiac arrhythmias and sudden death [D] . Wu, Ling 2008

机译：SCN5A（与心律不齐和猝死相关的心脏钠通道基因）的功能表征
8. Sudden Cardiac Death and Ventricular Arrhythmias Associated with Domperidone: Evidence Supporting Health Canada’s Warning [O] . Salmaan Kanji, Alyssa Stevenson, Brian Hutton 2014

机译：多潘立酮引起的心源性猝死和室性心律失常：支持加拿大卫生部的警告的证据
9. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society [O] . 2006

机译：ACC / AHA / ESC 2006患有心间心律失常患者和预防突发心脏死亡患者的指南 - 执行摘要：美国心脏病学院/美国心脏协会工作队和欧洲心脏病学会的实践指南的报告（写作委员会为欧洲心律协会和心律社会合作开发的心室心律失常患者管理准则和预防突然的心脏死亡）
10. The Onset of Myocardial Infarction and Sudden Cardiac Death - Pathological and Retrospective History Study of Sudden Death and Myocardial Infarction in a Community. [R] . kuller,lewis cooper,malcolm 1972

机译：心肌梗死和心源性猝死的发病 - 社区猝死和心肌梗死的病理学和回顾性研究。

Metoclopramide, domperidone: sudden cardiac death, ventricular arrhythmia

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