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The invention of antidepressants

机译:抗抑郁药的发明

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摘要

60 million boxes of antidepressants, dispensed to around 5 million people, were reimbursed by France's national health insurance system in 2014 (1). Since the 1990s, patients diagnosed with depression by their doctor have more and more often been prescribed drugs, aimed at reducing the duration of the depressive episode and preventing relapses or progression to a chronic condition (2). The success of these drugs can be explained in part by history. Calming versus aggressive therapies Since ancient times, writings have described the existence of disorders which today we call depression. Two states have often been distinguished, under names which have changed over the centuries: on the one hand, a reaction to an event, which fades with time, and on the other hand, persisting symptoms, with no explicable cause, which was called melancholia in the 19th century (3,4). The psychological, biological, social and genetic causes of these disorders are still debated today within the scientific community.
机译:2014年,法国国家医疗保险系统向大约500万人发放了6000万箱抗抑郁药(1)。自20世纪90年代以来,医生诊断为抑郁症的患者越来越多地使用处方药,旨在缩短抑郁症发作的持续时间,防止复发或发展为慢性疾病(2)。这些药物的成功部分可以用历史来解释。从古到今,文献描述了抑郁症的存在,我们称之为抑郁症。有两种状态经常被区分开来,它们的名称在几个世纪里发生了变化:一方面是对一个事件的反应,随着时间的推移逐渐消失;另一方面是持续的症状,没有可解释的原因,在19世纪被称为忧郁症(3,4)。这些疾病的心理、生物学、社会和遗传原因至今仍在科学界争论不休。

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    《Prescrire international》 |2021年第222期|共3页
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  • 正文语种 eng
  • 中图分类 药学;
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