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NSAIDs: complications of sinusitis

机译：NSAIDS：鼻窦炎并发症

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In late 2019, French teams analysed the medical files of patients aged less than 18 years who had been admitted to four university hospitals with frontoethmoidal sinusitis over a two-year period (1). 120 children (with a median age of 8 years) were identified. All had fever and headache. They were hospitalised for 6 days on average after the onset of symptoms. Thirty of these children had taken ibuprofen prescribed for an average period of 6.2 days, at the recommended dosage based on body weight. In total, 28 children had intracranial complications and 40 had orbital complications (1). Complications of sinusitis are rare and include, in particular, periorbital cellulitis, meningitis and intracranial abscess (2). The incidence of these infectious locoregional complications was around 5-fold greater in children exposed to ibuprofen than in the unexposed group, a statistically significant difference with an estimated relative risk (RR) of 4.8 and a 95% confidence interval (95CI) of 1.8 to 12.9. The difference mainly concerned intracranial complications (RR=2.8; 95CI: 1.1 to 7.2) (1).
机译：2019年末，法国团队分析了年龄小于18岁的患者的医疗档案，这些患者因额窦鼻窦炎在两年内入住四所大学医院（1）。确定了120名儿童（中位年龄为8岁）。所有人都发烧和头痛。他们在症状出现后平均住院6天。其中30名儿童服用了布洛芬，平均服用时间为6.2天，剂量根据体重而定。总共有28名儿童出现颅内并发症，40名儿童出现眼眶并发症（1）。鼻窦炎的并发症很少见，尤其包括眶周蜂窝织炎、脑膜炎和颅内脓肿（2）。暴露于布洛芬的儿童感染性局部并发症的发生率约为未暴露组的5倍，具有统计学意义的差异，估计相对风险（RR）为4.8，95%可信区间（95CI）为1.8至12.9。差异主要与颅内并发症有关（RR=2.8；95CI:1.1至7.2）（1）。

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    《Prescrire international》 |2021年第222期|共1页
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  • 正文语种 eng
  • 中图分类 药学;
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