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首页> 外文期刊>Preventive Nutrition and Food Science >Beneficial Effects of Algerian Green Alga Ulva lactuca and Its Hydroethanolic Extract on Insulin Resistance and Cholesterol Reverse Transport in High-Fat/Streptozotocin Diabetic Rats
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Beneficial Effects of Algerian Green Alga Ulva lactuca and Its Hydroethanolic Extract on Insulin Resistance and Cholesterol Reverse Transport in High-Fat/Streptozotocin Diabetic Rats

机译：阿尔及利亚绿藻藻藻苜蓿及其氢丙醇提取物对高脂/链脲佐菌素糖尿病大鼠胰岛素抵抗和胆固醇逆转的效果

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摘要

The aim of this study was to evaluate the impact of the green algae Ulva lactuca and its hydroethanolic extract on insulin resistance and cholesterol reverse transport in type 2 diabetic (T2D) rats. Rats had T2D induced by a high-fat diet (HFD) for 5weeks followed by intraperitoneal injection of streptozotocin. Diabetic rats were divided into three groups and were fed a HFD in the presence or absence of 1% alga (HFD-Alg) or 1% of its hydroethanolic extract (HFD-Ext), for 4 weeks. The control group consumed 20% casein combined with 5% lipids. Hyperglycemia, insulin resistance, hypercholesterolemia, and hypertriglyceridemia were noted in HFD rats vs control rats. Whole alga and its extract decreased these parameters vs the HFD. Moreover, fecal totalcholesterol and triacylglycerols levels were lowered in HFD group vs C group, but were increased with HFD-Alg vs HFD. Compared with the Control, the HFD group had decreased lecithin:cholesterol acyltransferase (LCAT) activity, apolipoprotein A-I (ApoA-I), high-density lipoprotein (HDL_3)-phospholipids (PL), and HDL_2-cholesteryl ester (CE) levels, but increased HDL_3-unesterified cholesterol (UC) levels. Furthermore, compared with the HFD group, the HFD-Alg and HFD-Ext groups had increased LCAT activity, ApoA-I, HDL_3-PL, and HDL_2-CE levels and decreased HDL_3-UC levels. In addition, in the HFD-Ext group, LCAT activity and ApoA-1 levels were decreased vs the HFD-Alg whereas HDL3-UC levels were increased. In conclusion, these results indicate that U. lactuca and its hydroethanolic extract have curative effect on T2D. Therefore, this alga could be considered a functional food supplement for the treatment and prevention of diabetes.
机译：本研究旨在评估绿藻石莼及其水乙醇提取物对2型糖尿病（T2D）大鼠胰岛素抵抗和胆固醇逆向转运的影响。大鼠用高脂饮食（HFD）诱导T2D，持续5周，然后腹腔注射链脲佐菌素。将糖尿病大鼠分为三组，在有无1%海藻（HFD Alg）或1%其水乙醇提取物（HFD Ext）的情况下喂食HFD 4周。对照组摄入20%酪蛋白和5%脂质。与对照组相比，HFD大鼠出现高血糖、胰岛素抵抗、高胆固醇血症和高甘油三酯血症。与HFD相比，全藻及其提取物降低了这些参数。此外，HFD组与C组相比，粪便总胆固醇和三酰甘油水平降低，但HFD Alg组与HFD组相比，粪便总胆固醇和三酰甘油水平升高。与对照组相比，HFD组卵磷脂：胆固醇酰基转移酶（LCAT）活性、载脂蛋白A-I（ApoA-I）、高密度脂蛋白（HDL_3）-磷脂（PL）和HDL_2-胆固醇酯（CE）水平降低，但HDL_3-未酯化胆固醇（UC）水平升高。此外，与HFD组相比，HFD Alg和HFD Ext组的LCAT活性、ApoA-I、HDL_3-PL和HDL_2-CE水平增加，HDL_3-UC水平降低。此外，与HFD Alg相比，HFD Ext组的LCAT活性和ApoA-1水平降低，而HDL3-UC水平升高。综上所述，这些结果表明乳香及其水乙醇提取物对T2D有疗效。因此，这种海藻可以被认为是治疗和预防糖尿病的功能性食品补充剂。

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