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首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering in Medicine >An in vitro assessment of atrial fibrillation flow types on cardiogenic emboli trajectory paths
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An in vitro assessment of atrial fibrillation flow types on cardiogenic emboli trajectory paths

机译：心肌栓塞轨迹路径上心房颤动流动类型的体外评估

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摘要

Atrial fibrillation is the most significant contributor to thrombus formation within the heart and is responsible for 45% of all cardio embolic strokes, which account for approximately 15% of acute ischemic strokes cases worldwide. Atrial fibrillation can result in a reduction of normal cardiac output and cycle length of up to 30% and 40%, respectively. A total of 240 embolus analogues were released into a thin-walled, patient-specific aortic arch under normal (60 embolus analogues) and varying atrial fibrillation (180 embolus analogues) pulsatile flow conditions. Under healthy flow conditions (n = 60), the embolus analogues tended to follow the flow rate split through each outlet vessel. There was an increase in clot trajectories along the common carotid arteries under atrial fibrillation flow conditions. A shorter pulse period (0.3 s) displayed the highest percentage of clots travelling to the brain (24%), with a greater percentage of clots travelling through the left common carotid artery (17%). This study provides an experimental insight into the effect varying cardiac output and cycle length can have on the trajectory of a cardiac source blood clots travelling to the cerebral vasculature and possibly causing a stroke.
机译：心房颤动是心脏内血栓形成的最重要因素，占所有心源性栓塞卒中的45%，约占全球急性缺血性卒中病例的15%。心房颤动可导致正常心输出量和周期长度分别减少30%和40%。在正常（60个栓子类似物）和不同的心房颤动（180个栓子类似物）脉动流条件下，共有240个栓子类似物释放到薄壁的、患者特有的主动脉弓中。在健康流量条件下（n=60），栓子类似物倾向于遵循通过每个出口血管的流速。在心房颤动血流条件下，沿着颈总动脉的血栓轨迹增加。较短的脉冲周期（0.3秒）显示，进入大脑的血栓百分比最高（24%），而通过左颈总动脉的血栓百分比更高（17%）。这项研究提供了一个实验洞察，不同的心输出量和周期长度可能会对心源性血块流向脑血管的轨迹产生影响，并可能导致中风。

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