Ketamine Hydrochloride 10%, Gabapentin 10%, and Ketoprofen 10% in Lipoderm

Loyd V. Allen; Jr.

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Ketamine Hydrochloride 10%, Gabapentin 10%, and Ketoprofen 10% in Lipoderm

机译：盐酸氯胺酮10％，加巴普丁10％，乙二醇10％在脂质胚胎中

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Method of Preparation: Calculate the required quantity of each ingredient for the total amount to be prepared. Accurately weigh or measure each ingredient. Blend the powders together thoroughly. Add the propylene glycol and mix well. Geometrically, incorporate the Lipoderm or other penetrating base of choice with thorough mixing after each addition. Package and label. Use: This preparation has been used in the treatment of complex regional pain syndrome (CRPS) and other pain disorders. Packaging: Package in tight, light-resistant containers. Labeling: Keep out of reach of children. Discard after [time period]. Stability: A beyond-use date of 30 days may be used if water is present in the penetrating base, or up to 6 months if the base is anhydrous. Quality Control: Quality-control assessment can include theoretical weight compared with actual weight, specific gravity, active drug assay, color, texture-surface, texture-spatula spread, appearance, feel, rheologic properties, and physical observations. Discussion: CRPS is a progressive, multifactorial condition that usually develops in a limb following trauma or surgery. Treatments for this condition are limited, so the use of topical ketamine and other agents is promising, especially given the favorable safety profile of topical agents.

机译：制备方法：计算每种成分所需的总制备量。准确称量或测量每种成分。把粉末充分混合在一起。加入丙二醇并充分混合。在几何结构上，每次添加后彻底混合脂皮或其他渗透基底。包装和标签。用途：该制剂已用于治疗复杂区域疼痛综合征（CRPS）和其他疼痛疾病。包装：用密封、耐光的容器包装。标签：放在儿童够不着的地方。在[时间段]后丢弃。稳定性：如果渗透性基底中存在水，则可使用30天的过期日期，如果基底是无水的，则最多可使用6个月。质量控制：质量控制评估可以包括理论重量与实际重量的比较、比重、活性药物分析、颜色、质地表面、质地抹刀涂抹、外观、手感、流变特性和物理观察。讨论：CRPS是一种进行性多因素疾病，通常在创伤或手术后发生在肢体。这种情况的治疗是有限的，因此局部使用氯胺酮和其他药物是有希望的，特别是考虑到局部药物的良好安全性。

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《U. S. pharmacist》 |2021年第3期|共2页
作者
Loyd V. Allen; Jr.;
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Professor Emeritus College of Pharmacy University of Oklahoma Oklahoma City;

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原文格式 PDF
正文语种 eng
中图分类药学;
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Ketamine Hydrochloride 10%, Gabapentin 10%, and Ketoprofen 10% in Lipoderm

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