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首页> 外文期刊>Psychiatry Research. Neuroimaging >Acute change in anterior cingulate cortex GABA, but not glutamine/glutamate, mediates antidepressant response to citalopram
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Acute change in anterior cingulate cortex GABA, but not glutamine/glutamate, mediates antidepressant response to citalopram

机译：前型刺痛皮层GABA的急性变化，但不是谷氨酰胺/谷氨酸，介导西酞普兰的抗抑郁药反应

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Abstract Little is known about the acute effects of antidepressant treatments on brain glutamate and gamma-amino-butyric acid (GABA) levels, and their association with clinical response. Using proton magnetic resonance spectroscopy ( 1 H-MRS) we examined longitudinally the effects of citalopram on glutamine/glutamate ratios and GABA levels in the pregenual anterior cingulate cortex (pgACC) of individuals with major depressive disorder (MDD). We acquired 1 H-MRS scans at baseline and at days 3, 7, and 42 of citalopram treatment in nineteen unmedicated individuals with MDD. Ten age- and sex-matched non-depressed comparison individuals were scanned once. The association between 1) baseline metabolites and 2) change in metabolites from baseline to each time point and clinical response (change in Montgomery-?sberg Depression Rating Scale (MADRS) score from baseline to day 42) was assessed by longitudinal regression analysis using generalized estimating equations. Contrary to our hypotheses, no significant associations emerged between glutamate metabolites and clinical response; however, greater increases (or smaller decreases) in pgACC GABA levels from baseline to days 3 and 7 of citalopram treatment were significantly associated with clinical response. These findings suggest that an acute change in GABA levels in pgACC predicts, and possibly mediates, later clinical response to citalopram treatment in individuals with MDD. Highlights ? Little is known about how antidepressants acutely impact brain glutamate and GABA levels. ? Citalopram response is associated with an early increase in brain GABA levels. ? Citalopram response is not associated with an early increase in brain glutamate levels.
机译：摘要关于抗抑郁药治疗对大脑谷氨酸和γ-氨基丁酸（GABA）水平的急性影响及其与临床反应的关系，我们知之甚少。利用质子磁共振波谱（1H-MRS），我们纵向研究了西酞普兰对重度抑郁症（MDD）患者的前扣带回皮质（pgACC）谷氨酰胺/谷氨酸比值和GABA水平的影响。我们在基线检查时以及西酞普兰治疗的第3、7和42天对19名MDD患者进行了1H-MRS扫描。10名年龄和性别匹配的非抑郁对照个体被扫描一次。1）基线代谢物和2）从基线到每个时间点的代谢物变化与临床反应（蒙哥马利-斯伯格抑郁评分量表（MADRS）评分从基线到第42天的变化）之间的关联通过使用广义估计方程的纵向回归分析进行评估。与我们的假设相反，谷氨酸代谢物与临床反应之间没有显著关联；然而，从基线检查到西酞普兰治疗的第3天和第7天，pgACC GABA水平的更高（或更小的降低）与临床反应显著相关。这些发现表明，pgACC中GABA水平的急性变化预测并可能介导MDD患者对西酞普兰治疗的后期临床反应。亮点？关于抗抑郁药如何对大脑谷氨酸和GABA水平产生急性影响，我们知之甚少？西酞普兰的反应与大脑GABA水平的早期升高有关？西酞普兰反应与早期脑谷氨酸水平升高无关。

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