Abstract Prevalence of depressive symptoms and their association with brainstem raphe echogenicity in patients with Parkinson's disease and non-PD controls
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Psychiatry Research. Neuroimaging >Prevalence of depressive symptoms and their association with brainstem raphe echogenicity in patients with Parkinson's disease and non-PD controls
【24h】

Prevalence of depressive symptoms and their association with brainstem raphe echogenicity in patients with Parkinson's disease and non-PD controls

机译：帕金森病和非Pd控制患者抑郁症状及其与脑干Raphehehity的关联患病率

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Despite advances in diagnostics and clinical recognition, depressive symptoms in Parkinson's disease (PD) exceeding normal limits remain effectively untreated. In this study, we report on the prevalence and severity of depressive symptoms as well as their association with brainstem raphe echogenicity in patients with PD and non-PD controls. The study included 266 Estonian PD patients and 168 age- and education-matched controls. Demographic and clinical data was documented. Brainstem raphe (BR) was visualized by transcranial sonography (TCS). The prevalence of depressive symptoms in the patient sample was found to be significantly higher than in controls. BR echogenicity in both patients and controls was directly related to their total BDI score, although we found a significantly greater reduction of BR echogenicity in patients with PD and depressive symptoms compared to depressed non-PD controls. The present results corroborate the hypothesis that morphological alteration of the BR is involved in the pathogenesis of depressive disorders. TCS of BR could be used as a non-invasive biomarker to improve detection of depressive symptoms in early PD stages where clinicians may not recognize affective disturbances in the context of PD phenomena. Highlights ? Prevalence of depressive symptoms in PD was significantly higher than in controls. ? BR echogenicity in patients and controls was directly related to their BDI score. ? Morphological alteration of the BR is involved in PD-associated depressive disorders. ]]>
机译：摘要尽管在诊断和临床识别方面取得了进步，帕金森病（PD）的抑郁症状仍然存在超过正常限度的疾病仍然没有得到有效治疗。在这项研究中，我们报告了帕金森病患者和非帕金森病对照者抑郁症状的患病率和严重程度及其与脑干中缝回声的关系。这项研究包括266名爱沙尼亚PD患者和168名年龄和教育匹配的对照组。记录人口统计学和临床数据。经颅超声（TCS）显示脑干中缝（BR）。患者样本中抑郁症状的患病率明显高于对照组。患者和对照组的BR回声与他们的BDI总分直接相关，尽管我们发现PD和抑郁症状患者的BR回声比抑郁非PD对照组显著降低。目前的结果证实了BR的形态改变参与抑郁症发病机制的假说。BR的TCS可作为一种非侵入性生物标记物，用于改善PD早期阶段抑郁症状的检测，在PD早期阶段，临床医生可能无法识别PD现象背景下的情感障碍highlights帕金森病患者抑郁症状的患病率显著高于对照组。？BR患者和对照组的回声与他们的BDI评分直接相关。“>BR的形态改变与PD相关的抑郁症有关。]>

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号