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首页> 外文期刊>Psychiatry Research. Neuroimaging >The association between in vivo central noradrenaline transporter availability and trait impulsivity
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The association between in vivo central noradrenaline transporter availability and trait impulsivity

机译：在体内非甲肾上腺素转运蛋白可用性和特质冲动之间的关联

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摘要

The brain noradrenaline (NA) system, particularly NA transporters (NAT), are thought to play an important role in modulating impulsive behavior. Impaired impulsivity is implicated in a variety of neuropsychiatric conditions; however, an in vivo link between central NAT availability and human impulsivity has not been shown. Using positron emission tomography (PET) and S,S-[C-11] O-methylreboxetine (MRB), we tested whether NAT availability is associated with this basic behavioral trait based on the Barratt Impulsiveness Scale (BIS-11) in twenty healthy individuals (12 females, 33.8 +/- 9.3, 21-52 years of age) with a body mass index (BMI) ranging from 21.7 kg/m(2) to 47.8 kg/m(2). Applying both voxel-wise and volume-of-interest (VOI) based analyses, we found that distribution volume ratios (DVR) used as PET outcome measures negatively correlated with BIS-11 total scores in the orbitofrontal cortex (OFC) and in the hippocampus as well as in parts of the cerebellar cortex. These associations however did not remain after correction for multiple testing. Thus, although it appears that low NAT availability is associated with greater scores of impaired behavioral control, this needs to be confirmed in a larger series of individuals with highly impulsive behavior.
机译：大脑去甲肾上腺素（NA）系统，尤其是NA转运体（NAT），被认为在调节冲动行为中起着重要作用。冲动性受损与多种神经精神疾病有关；然而，中枢NAT可用性和人类冲动性之间的体内联系尚未显示。利用正电子发射断层扫描（PET）和S，S-[C-11]邻甲基雷波西汀（MRB），我们根据Barratt冲动量表（BIS-11）测试了20名健康个体（12名女性，33.8+/-9.3岁，21-52岁）的NAT可用性是否与这一基本行为特征相关，这些健康个体的体重指数（BMI）在21.7 kg/m（2）到47.8 kg/m（2）之间。应用基于体素和感兴趣体积（VOI）的分析，我们发现用作PET结果测量的分布容积比（DVR）与眶额皮质（OFC）、海马以及部分小脑皮质的BIS-11总分呈负相关。然而，在多次测试校正后，这些关联并没有保留下来。因此，尽管NAT可用性低似乎与行为控制受损的分数更高有关，但这需要在一系列具有高度冲动行为的个体中得到证实。

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  • 来源
    《Psychiatry Research. Neuroimaging》 |2017年第2017期|共6页
  • 作者

    Hesse Swen; Mueller Ulrich; Rullmann Michael; Luthardt Julia; Bresch Anke; Becker Georg -Alexander; Zientek Franziska; Patt Marianne; Meyer Philipp M.; Blueher Matthias; Strauss Maria; Fenske Wiebke; Hankir Mohammed; Ding Yu-Shin; Hilbert Anja; Sabri Osama;

  • 作者单位

    Univ Leipzig Integrated Treatment &

    Res Ctr IFB AdiposityDis Med Ctr Liebigstr 20 D-04103;

    Univ Cambridge Dept Psychiat &

    Behav Downing St Cambridge CB2 3EB England;

    Univ Leipzig Dept Nucl Med Liebigstr 18 D-04103 Leipzig Germany;

    Univ Leipzig Dept Nucl Med Liebigstr 18 D-04103 Leipzig Germany;

    Univ Leipzig Dept Nucl Med Liebigstr 18 D-04103 Leipzig Germany;

    Univ Leipzig Dept Nucl Med Liebigstr 18 D-04103 Leipzig Germany;

    Univ Leipzig Integrated Treatment &

    Res Ctr IFB AdiposityDis Med Ctr Liebigstr 20 D-04103;

    Univ Leipzig Dept Nucl Med Liebigstr 18 D-04103 Leipzig Germany;

    Univ Leipzig Dept Nucl Med Liebigstr 18 D-04103 Leipzig Germany;

    Univ Leipzig Integrated Treatment &

    Res Ctr IFB AdiposityDis Med Ctr Liebigstr 20 D-04103;

    Univ Leipzig Dept Psychiat &

    Psychotherapy Semmelweisstr 10 D-04103 Leipzig Germany;

    Univ Leipzig Integrated Treatment &

    Res Ctr IFB AdiposityDis Med Ctr Liebigstr 20 D-04103;

    Univ Leipzig Integrated Treatment &

    Res Ctr IFB AdiposityDis Med Ctr Liebigstr 20 D-04103;

    NYU Dept Radiol &

    Psychiat Sch Med 550 1st Ave New York NY 10016 USA;

    Univ Leipzig Integrated Treatment &

    Res Ctr IFB AdiposityDis Med Ctr Liebigstr 20 D-04103;

    Univ Leipzig Integrated Treatment &

    Res Ctr IFB AdiposityDis Med Ctr Liebigstr 20 D-04103;

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  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Noradrenaline; Noradrenaline transporter; PET; PET imaging; Impulsivity;

    机译：去甲肾上腺素;去甲肾上腺素运输器;宠物;宠物成像;冲动;

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