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首页> 外文期刊>Psychiatry Research. Neuroimaging >Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naive major depressive disorder patients
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Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naive major depressive disorder patients

机译：色氨酸羟化酶-2多态性与第一集发作的白质完整性有关，药物幼稚主要抑郁症患者

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摘要

Considerable evidence suggests that the tryptophan hydroxylase-2 (TPH2) gene is associated with the pathophysiology of major depressive disorder (MDD). In the present study, we investigated alterations of white matter (WM) integrity and the impact of TPH2 polymorphism on WM in a sample of 118 first-episode, medication-naive, MDD patients and 118 well-matched healthy controls. Whole brain analyses of fractional anisotropy (FA) were performed using tract-based spatial statistics (TBSS). The results showed that the MDD group had significantly reduced FA values for the genu and body of the corpus callosum (CC) and the bilateral anterior corona radiate (ACR). In the MDD patient group, the GG homozygote subgroup exhibited a widespread reduction of FA (uncorrected) and significantly reduced FA in the left retrolenticular portion of the internal capsule and left superior longitudinal fasciculus (SLF) compared with those of the T carriers (GT/TT) (FWE corrected). No significant correlation was found between the FA values in any brain region and the patients' clinical variables. Our findings demonstrate the presence of abnormal white matter integrity in untreated patients with first-episode depression. TPH2-rs4570625 polymorphisms may be involved in the pathological mechanism of WM micro-architecture in patients.
机译：大量证据表明，色氨酸羟化酶-2（TPH2）基因与重度抑郁症（MDD）的病理生理学有关。在本研究中，我们调查了118名首发、未服药、MDD患者和118名匹配良好的健康对照者的白质（WM）完整性改变以及TPH2多态性对WM的影响。利用基于束的空间统计（TBSS）对分数各向异性（FA）进行全脑分析。结果表明，MDD组显著降低了胼胝体（CC）和双侧放射前冠（ACR）的膝部和身体的FA值。在MDD患者组中，与T携带者（GT/TT）相比，GG纯合子亚组的内囊左晶状体后部分和左上纵束（SLF）的FA普遍减少（未纠正），且显著减少（FWE纠正）。在任何脑区的FA值与患者的临床变量之间均未发现显著相关性。我们的研究结果表明，未经治疗的首发抑郁症患者存在异常的白质完整性。TPH2-rs4570625多态性可能参与了患者西医微结构的病理机制。

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  • 来源
    《Psychiatry Research. Neuroimaging》 |2019年第1期|共7页
  • 作者

    Ping Liangliang; Xu Jian; Zhou Cong; Lu Jin; Lu Yi; Shen Zonglin; Jiang Linlin; Dai Nan; Xu Xiufeng; Cheng Yuqi;

  • 作者单位

    Kunming Med Univ Dept Psychiat Affiliated Hosp 1 295 Xichang RD Kunming 650032 Yunnan Peoples;

    Kunming Med Univ Dept Rheumatol &

    Immunol Affiliated Hosp 1 Kunming Yunnan Peoples R China;

    Kunming Med Univ Dept Psychiat Affiliated Hosp 1 295 Xichang RD Kunming 650032 Yunnan Peoples;

    Kunming Med Univ Dept Psychiat Affiliated Hosp 1 295 Xichang RD Kunming 650032 Yunnan Peoples;

    Kunming Med Univ Imaging Ctr Affiliated Hosp 1 Kunming Yunnan Peoples R China;

    Kunming Med Univ Dept Psychiat Affiliated Hosp 1 295 Xichang RD Kunming 650032 Yunnan Peoples;

    Kunming Med Univ Dept Psychiat Affiliated Hosp 1 295 Xichang RD Kunming 650032 Yunnan Peoples;

    Kunming Med Univ Dept Psychiat Affiliated Hosp 1 295 Xichang RD Kunming 650032 Yunnan Peoples;

    Kunming Med Univ Dept Psychiat Affiliated Hosp 1 295 Xichang RD Kunming 650032 Yunnan Peoples;

    Kunming Med Univ Dept Psychiat Affiliated Hosp 1 295 Xichang RD Kunming 650032 Yunnan Peoples;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    TPH2; Major depressive disorder; TBSS; White matter;

    机译：TPH2;主要抑郁症;TBSS;白质;

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