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首页> 外文期刊>Psychiatry Research. Neuroimaging >Reduced left ventrolateral prefrontal cortex activation during verbal fluency tasks is associated with suicidal ideation severity in medication-naive young adults with major depressive disorder: A functional near-infrared spectroscopy study
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Reduced left ventrolateral prefrontal cortex activation during verbal fluency tasks is associated with suicidal ideation severity in medication-naive young adults with major depressive disorder: A functional near-infrared spectroscopy study

机译：在口头流畅性任务期间减少左侧腹外侧前额定皮质激活与主要抑郁症的药物幼稚年轻成年人的自杀性致畸严重程度有关：功能近红外光谱研究

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摘要

The reduction in the oxygenation dynamics in the prefrontal cortex (PFC) during cognitive tasks is a well-known occurrence in major depressive disorders (MDD). Studies focusing on oxygenation changes in the PFC in individuals with suicidal ideation are limited. Therefore, this study investigated and confirmed the presence of prefrontal dysfunction depending on the intensity of suicidal ideation among 77 young adults (45 patients with MDD and 32 healthy controls) using near-infrared spectroscopy (NIRS). All participants underwent assessment with the Beck Depression Inventory-II, Beck Anxiety Inventory, and Beck Scale for Suicidal ideation. NIRS revealed relative hypofunction in the left dorsolateral PFC, left ventrolateral PFC (LVLPFC), and both orbitofrontal cortices in young adults with MDD compared to that in the healthy controls during verbal fluency tasks. Furthermore, the oxyhaemoglobin changes in the LVLPFC mediated the indirect effect of depression severity on suicidal ideation intensity. Our results confirmed that functional NIRS is a useful auxiliary tool for objectively assessing the risk of suicidal ideation.
机译：认知任务期间前额叶皮质（PFC）的氧合动力学降低是抑郁症（MDD）的常见现象。专注于自杀意念个体PFC氧合变化的研究有限。因此，本研究利用近红外光谱（NIRS）技术对77名年轻人（45名MDD患者和32名健康对照）的自杀意念强度进行了调查并证实了前额叶功能障碍的存在。所有参与者都接受了贝克抑郁量表II、贝克焦虑量表和贝克自杀意念量表的评估。NIRS显示，在语言流畅性任务中，与健康对照组相比，患有MDD的年轻人的左背外侧PFC、左腹外侧PFC（LVLPFC）和两个眶额皮质功能相对低下。此外，LVLPFC中的氧合血红蛋白变化介导了抑郁严重程度对自杀意念强度的间接影响。我们的结果证实，功能性NIRS是客观评估自杀意念风险的有用辅助工具。

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